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Table 3 Mean levels of metabolic syndrome-related anthropometric, biological and clinical parameters in subjects without metabolic syndrome according to the 5 polymorphisms

From: The APOA5Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides

APOA5 Ser19Trp

Ser19Ser

Ser19Trp

Trp19Trp

p

p a

p b

Waist (cm)

85 ± 11

84 ± 11

81 ± 8

0.49

0.23

0.77

TG (mmol/l) d

1.26 ± 1.1

1.59 ± 2.4

2.46 ± 2.3

<0.0001 c

<0.0001 c

0.07 c

HDL (mmol/l) d

1.48 ± 0.4

1.49 ± 0.5

1.2 ± 0.5

0.56

0.78

0.59

Glucose (mmol/l) e

5.4 ± 1

5.4 ± 0.8

5.5 ± 0.4

0.72

0.43

0.83

SBP (mm Hg) f

129 ± 17

131 ± 18

135 ± 13

0.081

0.03

0.47

DBP (mm Hg) f

81 ± 11

82 ± 10

84 ± 10

0.082

0.03

0.39

APOA5 -12,238 T>C

TT

TC

CC

   

Waist (cm)

85 ± 11

85 ± 11

85 ± 11

0.49

0.23

0.15

TG (mmol/l) d

1.31 ± 1.0

1.29 ± 1.4

1.32 ± 1.9

0.01 c

0.003 c

0.08 c

HDL (mmol/l) d

1.47 ± 0.4

1.49 ± 0.4

1.52 ± 0.5

0.04

0.02

0.10

Glucose (mmol/l) e

5.4 ± 1

5.4 ± 1.1

5.3 ± 0.8

0.31

0.52

0.15

SBP (mm Hg) f

129 ± 17

129 ± 18

129 ± 17

0.24

0.11

0.30

DBP (mm Hg) f

81 ± 11

81 ± 11

81 ± 10

0.79

0.54

0.49

APOA4 Thr347Ser

Thr347Thr

Thr347Ser

Ser347Ser

   

Waist (cm)

85 ± 11

86 ± 11

86 ± 11

0.64

0.71

0.39

TG (mmol/l) d

1.31 ± 1

1.30 ± 1.8

1.22 ± 0.8

0.11 c

0.04 c

0.69 c

HDL (mmol/l) d

1.48 ± 0.4

1.49 ± 0.4

1.55 ± 0.5

0.24

0.24

0.09

Glucose (mmol/l) e

5.4 ± 1.1

5.4 ± 0.9

5.2 ± 0.7

0.44

0.63

0.20

SBP (mm Hg) f

130 ± 18

129 ± 17

127 ± 16

0.09

0.03

0.82

DBP (mm Hg) f

81 ± 11

81 ± 11

81 ± 10

0.92

0.83

0.84

APOC3 -482 C>T

CC

CT

TT

   

Waist (cm)

85 ± 11

85 ± 11

85 ± 11

0.75

0.78

0.49

TG (mmol/l) d

1.27 ± 1

1.34 ± 1

1.33 ± 1

0.09 c

0.04 c

0.07 c

HDL (mmol/l) d

1.47 ± 0.4

1.49 ± 0.4

1.51 ± 0.4

0.68

0.54

0.66

Glucose (mmol/l) e

5.4 ± 1

5.4 ± 1

5.4 ± 0.8

0.93

0.78

0.87

SBP (mm Hg) f

129 ± 17

129 ± 18

128 ± 17

0.47

0.45

0.28

DBP (mm Hg) f

81 ± 10

81 ± 11

81 ± 11

0.93

0.72

0.85

APOC3 3238 C>G

CC

CG

GG

   

Waist (cm)

85 ± 11

86 ± 11

84 ± 15

0.25

0.1

0.66

TG (mmol/l) d

1.27 ± 1.4

1.44 ± 1.2

1.56 ± 1.2

<0.0001 c

<0.0001 c

0.05 c

HDL (mmol/l) d

1.49 ± 0.4

1.47 ± 0.4

1.43 ± 0.4

0.15

0.6

0.29

Glucose (mmol/l) e

5.4 ± 1

5.4 ± 0.8

5.5 ± 0.6

0.55

0.35

0.79

SBP (mm Hg) f

129 ± 17

129 ± 17

134 ± 21

0.19

0.52

0.28

DBP (mm Hg) f

81 ± 11

81 ± 11

84 ± 12

0.12

0.37

0.21

  1. p values ajusted on age, gender and center ; pa and pb values for a dominant and recessive models, respectively; canalyses on log-transformed data ; BMI : body mass index ; TG : triglycerides ; HDL : high density lipoprotein ; SBP/DBP : systolic and diastolic blood pressure ; Exclusion of subjects treated : d with fibrates, e oral antidiabetic or insulin, f BP lowering therapy.
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BMC Medical Genetics

ISSN: 1471-2350

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