Table 5 Genotype frequency distribution and association study in ADAM33 between AS and CTR
Genotype | Frequency, no.(%) | x2 P value | Odds ratio | ||
|---|---|---|---|---|---|
AS(n = 181) | CTR(n = 151) | (95% CI) | |||
rs2787094 | CC | 49(27.07) | 113(74.84) | <0.0001 | 0.12(0.08–0.20) |
CG | 78(43.09) | 32(21.19) | <0.0001 | 2.82(1.73–4.59) | |
GG | 54(29.84) | 6(3.97) | <0.0001 | 10.28(4.28–24.69) | |
rs2290089 | AA | 0 | 0 | ||
AG | 37(20.44) | 41(27.15) | 0.151 | ||
GG | 144(79.56) | 110(72.85) | 0.151 | ||
rs2280090 | AA | 4(2.21) | 0 | 0.1289 | |
AG | 49(27.07) | 12(7.95) | <0.0001 | 4.30(2.19–8.44) | |
GG | 128(70.72) | 139(92.05) | <0.0001 | 0.21(0.11–0.41) | |
rs2280091 | AA | 63(34.81) | 117(77.48) | <0.0001 | 0.16(0.10–0.25) |
AG | 78(43.09) | 29(19.21) | <0.0001 | 3.19(1.93–5.26) | |
GG | 40(22.10) | 5(3.31) | <0.0001 | 8.28(3.18–21.59) | |
rs3918396 | AA | 140(77.35) | 110(72.85) | 0.3437 | |
AG | 41(22.65) | 41(27.15) | 0.3437 | ||
GG | 0 | 0 | |||
rs612709 | AA | 0 | 0 | ||
AG | 44(24.31) | 11(7.28) | <0.0001 | 4.09(2.03–8.24) | |
GG | 137(75.69) | 140(92.72) | <0.0001 | 0.24(0.12–0.49) | |