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Table 4 Association of TCF7L2 variant rs7903146 on dichotomization of the patient cohort based on N34S SPINK1 and L26V CTSB mutation status

From: TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSBmutations in predicting diabetes

 

N34S SPINK1

  

L26V CTSB

  
 

Wild

Mutant

  

Wild

Mutant

  

rs7903146

MAF

MAF

OR (95% CI)

P

MAF

MAF

OR (95% CI)

P

Total Cohort

(n = 307)

(n = 148)

  

(n = 165)

(n = 236)

  
 

0.29

0.28

0.95 (0.70–1.30)

0.75

0.28

0.28

1.01 (0.74–1.38)

0.95

FCPD

(n = 129)

(n = 49)

  

(n = 65)

(n = 78)

  
 

0.31

0.35

1.13 (0.69–1.85)

0.63

0.28

0.36

1.42 (0.86–2.36)

0.17

TCP

(n = 178)

(n = 99)

  

(n = 100)

(n = 158)

  
 

0.27

0.24

0.87 (0.58–1.29)

0.48

0.28

0.24

0.83 (0.55–1.24)

0.36

FCPD vs TCP

        

OR

1.22 (0.85–1.73)

1.59 (0.93–2.70)

  

0.98 (0.60–1.61)

1.69 (1.11–2.56)

  

P

0.27

0.09

  

0.95

0.013*

  
  1. TCP, tropical calcific pancreatitis; FCPD, fibro-calculous pancreatic diabetes; MAF, Minor allele frequency; OR, odds ratio; CI, confidence interval; P, p value;
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BMC Medical Genetics

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