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Table 3 Estimates of the genotype and allele relative risks for the TCF7L2 variants in the cases and controls based on clinical diagnosis

From: TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSBmutations in predicting diabetes

 

SNP*

Het OR (95% CI)

P

Hom OR (95% CI)

P

&OR (95% CI)

P

TCP (n = 286) vs Controls

rs7903146

0.95 (0.71–1.28)

0.74

0.98 (0.59–1.61)

0.94

0.97 (0.78–1.21)

0.81

 

rs12255372

0.92 (0.68–1.26)

0.62

1.31 (0.72–2.36)

0.38

1.03 (0.81–1.31)

0.79

FCPD (n = 192) vs Controls

rs7903146

0.82 (0.58–1.16)

0.27

1.08 (0.62–1.87)

0.78

0.95 (0.74–1.22)

0.69

 

rs12255372

1.03 (0.73–1.46)

0.86

0.89 (0.41–1.92)

0.76

0.99 (0.75–1.31)

0.94

TCP vs FCPD

rs7903146

0.86 (0.58–1.28)

0.47

1.10 (0.58–2.08)

0.76

0.98 (0.73–1.30)

0.87

 

rs12255372

1.11 (0.75–1.65)

0.59

0.68 (0.30–1.55)

0.36

0.96 (0.70–1.31)

0.79

  1. SNP, single nucleotide polymorphism; TCP, tropical calcific pancreatitis; FCPD, fibro-calculous pancreatic diabetes; *baseline genotype at rs7903146-CC, rs12255372-GG; Het OR & Hom OR, genotype relative risk (GRR) for heterozygotes and homozygotes respectively (GRR was calculated by comparing with the baseline genotype); &, allelic OR; P, P value