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Table 2 The genotype and allele distribution of EGFR polymorphisms in ACS patients and controls

From: R497K polymorphism in epidermal growth factor receptor gene is associated with the risk of acute coronary syndrome

Polymorphism

Control

n = 210 (%)

ACS

n = 191 (%)

Crude OR

(95% CI)

Adjusted ORa

(95% CI)

Adjusted

P a

R497K

     

   genotypes

     

   Arg/Arg

45 (21.4)

32 (16.8)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

   Arg/Lys

107 (51.0)

79 (41.4)

1.04 (0.61–1.78)

1.07 (0.62–1.85)

0.807

   Lys/Lys

58 (27.6)

80 (41.9)

1.94 (1.10–3.41)

1.98 (1.12–3.49)

0.018

   alleles

     

   Arg allele frequency

197 (46.9)

143 (37.4)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

   Lys allele frequency

223 (53.1)

239 (62.6)

1.48 (1.11–1.96)

1.49 (1.12–1.98)

0.006

(CA)n repeats

     

Both (CA)n repeats < 20

35 (16.7)

33 (17.3)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

Any (CA)n repeats ≥ 20

175 (83.3)

158 (82.7)

0.96 (0.57–1.61)

0.97 (0.58–1.64)

0.911

  1. a adjusted for sex and age by the logistic regression model.