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Table 2 Odds ratios and 95% Confidence Intervals for the effect of each SNP on bladder cancer risk from unadjusted and adjusted logistic regression models (adjusted for age, sex, smoking status and exposure to dyes)

From: Analysis of variants in DNA damage signalling genes in bladder cancer

SNP rs number, function, allele substitution

Control minor allele frequency (published)*

No of rare alleles

Number of Cases

Number of Controls

Unadjusted OR (95% CI)

p value for un-adjusted OR

Adjusted OR (95% CI)

p value for adjusted OR

NBS1

        

rs1448 3'UTR A/G

0.06 (0.189)

0

670 (89.0)

695 (89.1)

1

 

1

 
  

1

81 (10.8)

85 (10.9)

0.99 (0.71–1.36)

0.94

0.98 (0.71–1.37)

0.91

  

2

2 (0.3)

0 (0)

NDa

 

ND

 

rs9995 3'UTR A/G

0.31 (0.36)

0

334 (44.2)

373 (47.5)

1

 

1

 
  

1

347 (46.0)

332 (42.3)

1.17 (0.95–1.44)

0.15

1.16 (0.94–1.44)

0.17

  

2

74 (9.8)

80 (10.2)

1.03 (0.73–1.40)

0.86

1.04 (0.73–1.48)

0.85

rs13312986 3'UTR A/G

0.01 (0.067)

0

717 (95.1)

765 (97.3)

1

 

1

 
  

1

36 (4.8)

21 (2.7)

1.83 (1.06–3.16)

0.02

1.72 (0.99–3.02)

0.06

  

2

1 (0.1)

0 (0)

ND

 

ND

 

rs1063054 3'UTR T/G

0.31 (0.33)

0

329 (44.3)

374 (47.8)

1

 

1

 
  

1

340 (45.8)

330 (42.2)

1.17 (0.95–1.45)

0.14

1.15 (0.93–1.44)

0.18

  

2

74 (10.0)

79 (10.1)

1.06 (0.75–1.51)

0.73

1.06 (0.75–1.53)

0.71

rs13312981 3'UTR A/G

0.006 (0.034)

0

751 (99.6)

771 (98.7)

1

 

1

 
  

1

3 (0.4)

10 (1.3)

0.31 (0.08–1.12)

0.05

0.35 (0.09–1.27)

0.11

  

2

0 (0)

0 (0)

ND

 

ND

 

rs2735383 3'UTR G/C

0.32 (0.335)

0

328 (44.6)

363 (47.1)

1

 

1

 
  

1

336 (45.7)

326 (42.3)

1.14 (0.92–1.41)

0.23

1.14 (0.92–1.41)

0.27

  

2

72 (9.8)

81 (10.5)

0.98 (0.69–1.40)

0.93

0.98 (0.69–1.40)

0.93

rs1063053 3'UTR C/T

0.32 (0.312)

0

331 (44.4)

370 (47.2)

1

 

1

 
  

1

340 (45.6)

334 (42.6)

1.14 (0.92–1.41)

0.23

1.13 (0.92–1.41)

0.25

  

2

74 (9.9)

80 (10.2)

1.03 (0.72–1.47)

0.85

1.04 (0.73–1.49)

0.83

rs1805794 NS G/C Glu185Gln

0.31 (0.306)

0

347 (46.4)

375 (47.6)

1

 

1

 
  

1

332 (44.4)

330 (41.9)

1.08 (0.88–1.34)

0.44

1.06 (0.86–1.32)

0.57

  

2

69 (9.2)

83 (10.5)

0.89 (0.63–1.28)

0.55

0.93 (0.65–1.33)

0.68

rs769420 NS G/A Leu266Pro

0.001 (0.033)

0

756 (99.7)

782 (99.7)

1

 

1

 
  

1

2 (0.3)

2 (0.3)

1.03 (0.15–7.36)

0.97

1.04 (0.14–7.54)

0.97

  

2

0 (0)

0 (0)

ND

 

ND

 

MRE11

        

rs2155209 3'UTR A/G

0.34 (0.27)

0

306 (41.0)

324 (41.9)

1

 

1

 
  

1

325 (43.6)

367 (47.5)

0.93 (0.76–1.16)

0.50

0.90 (0.72–1.12)

0.34

  

2

115 (15.4)

82 (10.6)

1.48 (1.07–2.05)

0.02

1.39 (1.00–1.94)

0.05

  

2v(0+1)

    

1.54 (1.13–2.08) b

0.01

rs1061956 3'UTR A/G

0.008 (0.04)

0

747 (98.8)

774 (98.5)

1

 

1

 
  

1

9 (1.2)

12 (1.5)

0.78 (0.33–1.86)

0.57

0.71 (0.29–1.72)

0.45

  

2

0 (0)

0 (0)

ND

 

ND

 

rs641936 5'UTR A/G

0.31 (0.45)

0

352 (47.9)

364 (47.4)

1

 

1

 
  

1

308 (41.9)

329 (42.8)

0.97 (0.78–1.20)

0.77

0.98 (0.79–1.21)

0.85

  

2

75 (10.2)

75 (9.8)

1.03 (0.73–1.47)

0.85

1.16 (0.81–1.67)

0.43

rs1805365 5'UTR T/C

0.008 (0.048)

0

727 (98.8)

763 (98.3)

1

 

1

 
  

1

9 (1.2)

13 (1.7)

0.73 (0.31–1.71)

0.47

0.66 (0.27–1.58)

0.35

  

2

0 (0)

0 (0)

ND

 

ND

 

rs535801 SS C/T

0.29 (0.417)

0

381 (52.1)

393 (51.2)

1

 

1

 
  

1

292 (40.0)

307 (40.0)

0.98 (0.79–1.21)

0.86

1.00 (0.81–1.25)

0.97

  

2

58 (7.9)

68 (8.9)

0.88 (0.60–1.28)

0.51

1.00 (0.68–1.49)

0.98

rs497763 3'UTR G/A

0.42 (0.488)

0

259 (34.5)

278 (35.4)

1

 

1

 
  

1

373 (49.7)

363 (46.2)

1.10 (0.88–1.38)

0.39

1.13 (0.90–1.42)

0.35

  

2

119 (15.9)

145 (18.5)

0.88 (0.66–1.18)

0.40

0.97 (0.72–1.32)

0.85

ATM

        

rs2234997 NS A/T Glu126Asp

0.001 (0.001)

0

744 (99.5)

784 (99.9)

1

 

1

 
  

1

4 (0.5)

1 (0.1)

4.22 (0.47–37.8)

0.15

4.20 (0.46–38.1)

0.20

  

2

0 (0)

0 (0)

ND

 

ND

 

rs3092856 NS C/T Tyr32His

0.001 (0.035)

0

753 (100)

788 (99.8)

1

 

1

 
  

1

0 (0)

2 (0.3)

ND

 

ND

 
  

2

0 (0)

0 (0)

ND

 

ND

 

rs582157 3'UTR T/A

0.46 (0.438)

0

215 (28.7)

220 (28.2)

1

 

1

 
  

1

380 (50.8)

400 (51.3)

0.97 (0.77–1.23)

0.81

0.98 (0.77–1.24)

0.85

  

2

153 (20.5)

160 (20.5)

0.98 (0.73–1.31)

0.88

1.00 (0.75–1.35)

0.96

rs1263936 3'UTR G/A

0.45 (0.375)

0

225 (30.2)

229 (29.5)

1

 

1

 
  

1

381 (51.1)

391 (50.3)

0.99 (0.79–1.25)

0.94

0.99 (0.78–1.25)

0.90

  

2

140 (18.8)

157 (20.2)

0.91 (0.68–1.22)

0.52

0.94 (0.70–1.27)

0.70

rs609261 5'UTR A/G

0.46 (0.49)

0

215 (28.6)

221 (28.3)

1

 

1

 
  

1

384 (51.1)

396 (50.6)

1.00 (0.79–1.26)

0.98

1.00 (0.79–1.27)

0.98

  

2

152 (20.2)

165 (21.1)

0.95 (0.71–1.26)

0.71

0.98 (0.73–1.31)

0.88

RAD50

        

rs1047382 NS A/G Ala558Val

0.001 (0.095)

0

755 (100)

789 (99.9)

1

 

1

 
  

1

0 (0)

1 (0.1)

ND

 

ND

 
  

2

0 (0)

0 (0)

ND

 

ND

 

H2AX

        

rs643788 3'UTR A/G

0.42 (0.491)

0

235 (31.8)

272 (35.1)

1

 

1

 
  

1

368 (49.8)

354 (45.7)

1.20 (0.96–1.51)

0.11

1.20 (0.95–1.51)

0.13

  

2

136 (18.4)

149 (19.2)

1.06 (0.80–1.41)

0.71

1.03 (0.76–1.38)

0.86

rs8551 3'UTR G/A

0.45 (0.485)

0

236 (31.5)

277 (35.4)

1

 

1

 
  

1

369 (49.2)

371 (47.4)

1.15 (0.93–1.46)

0.18

1.16 (0.92–1.46)

0.20

  

2

145 (19.3)

134 (17.1)

1.27 (0.95–1.70)

0.11

1.25 (0.93–1.69)

0.14

rs7350 INT G/A

0.36 (0.413)

0

286 (38.4)

325 (41.8)

1

 

1

 
  

1

353 (47.5)

342 (44.0)

1.17 (0.94–1.46)

0.15

1.20 (0.96–1.50)

0.11

  

2

105 (14.1)

111(14.3)

1.07 (0.79–1.47)

0.65

1.03 (0.75–1.41)

0.87

  1. a) ND – Not determined because of zero count for case or control population.
  2. b) The OR was calculated by comparing the rare homozygotes with the combined common homozygotes and heterozygotes as the bladder cancer risk appeared to be confined to the rare homozygotes.
  3. * Allele frequencies obtained from the Environmental Genome Project (EGP) via the National Center for Biotechnology Information (NCBI) at start of study (ie. pooled ethnicity)
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BMC Medical Genetics

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