Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study

Table 3 Replication of association in a sample of Caucasians enrolled in the FHS.

Marker	Minor Allele Frequency	Mean SBP/DBP By Genotype (mmHg)			P-Value
		Homozygous for major allele	Heterozygous	Homozygous for minor allele	SBP	DBP
rs2646159	0.07	126/75	124/75	127/68	0.12	0.14
rs3762528	0.06	125/75	127/75	137/81	0.30	0.25
rs2767	0.36	126/75	125/75	125/74	0.24	0.72
rs12996322	0.36	125/75	126/75	126/74	0.11	0.53
rs2099489	0.20	125/75	125/75	133/75	0.009	0.25

* Values given are p-values from the most significant genetic model (additive, dominant, recessive), controlling for age and sex. Results are given after removing those on antihypertensive medication from the analysis.

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