Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study

Table 2 Association analysis of polymorphisms in CHRNA1, CHRND and CHRNG with blood pressure in the AFDS.

Marker	Polymorphism	Minor Allele Frequency	Mean SBP/DBP By Genotype (mmHg)			P-Value
			Homozygous for major allele	Heterozygous	Homozygous for minor allele	SBP	DBP
CHRNA1
rs2646159	Intron 2	0.09	122/77	122/79	132/91	0.14	0.009
rs2305416	Exon 7: His320His	0.06	123/78	123/77	134/79	0.09	0.70
rs2646165	Intron 4	0.14	123/76	123/79	124/81	0.24	0.07
rs7560774	Intron 1	0.46	122/79	122/77	123/77	0.23	0.04
CHRND
rs2278478	Intron 2	0.29	122/77	123/78	123/80	0.32	0.45
rs3762528	Intron 9	0.09	121/77	126/79	113/78	0.0007	0.18
rs2767	Exon 12 UTR	0.43	121/79	125/80	128/81	0.0007	0.05
CHRNG
rs12996322	Intron 1	0.41	120/77	124/78	126/79	0.007	0.26
rs6761667	Intron 6	0.48	119/76	123/78	125/78	0.0001	0.007
rs2573206	Intron 8	0.19	120/77	121/77	123/78	0.03	0.04
rs13018423	Intron 8	0.29	122/77	123/78	125/78	0.31	0.63
rs2099489	Exon 12: Arg474Arg	0.20	121/77	124/78	127/78	0.0009	0.02

Values given are p-values from the most significant genetic model (additive, dominant, recessive), controlling for age and sex. Results are given after removing those on antihypertensive medication from the analysis.

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