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Table 1 Distribution of genotypes of the -2221 (C/T) insulin polymorphism in German patients with autoimmune endocrinopathies and healthy controls

From: Insulin gene polymorphisms in type 1 diabetes, Addison's disease and the polyglandular autoimmune syndrome type II

  

Genotype

    
  

CC

CT

TT

 

Allele

 

Group

n

n

%

n

%

n

%

p*

C%

T%

p*

HC

275

182

66.2

85

30.9

8

2.9

 

81.6

18.4

 

T1D

317

249

78.5

64

20.2

4

1.3

0.0027

88.6

11.4

8.9 × 10-4

HT

61

36

59.0

22

36.1

3

4.9

0.4898

77.0

23.0

0.2998

AD

107

73

68.2

25

23.4

9

8.4

0.0331

79.9

20.1

0.4738

APS-II

62

45

72.6

16

25.8

1

1.6

0.5870

85.5

14.5

0.3763

T1D + AIT

22

18

81.8

4

18.2

0

0

0.2898

90.9

9.1

0.2898

   T1D + HT

15

13

86.7

2

13.3

0

0

0.2479

93.3

6.7

0.1653

   T1D + GD

7

5

71.4

2

28.6

0

0

0.8851

85.7

14.3

0.9682

AD + AIT

33

22

66.7

10

30.3

1

3.0

0.9968

81.8

18.2

0.8948

   AD + HT

23

15

65.2

8

34.8

0

0

0.6790

82.6

17.4

0.9723

   AD + GD

10

7

70.0

2

20.0

1

10

0.3802

80.0

20.0

0.9138

T1D + AD + HT

7

5

71.4

2

28.6

0

0.0

0.8851

85.7

14.3

0.9682

  1. P values are given uncorrected
  2. *compared to healthy controls
  3. Not significant after correction