| Â | Heterogeneity Model |
|---|
| Â | Disease Allele Onlyg
| Markers Onlyh
| Disease and Markersi
|
|---|
One-Tailed p | Zc
| Zp
| Zc
| Zp
| Zc
| Zp
|
|---|
0.1
| 0.0966 | 0.0939 | 0.1153 | 0.1022 | 0.1038 | 0.0951 |
0.05
| 0.0471 | 0.0426 | 0.0626 | 0.0515 | 0.0527 | 0.0442 |
0.01
| 0.0087 | 0.0084 | 0.0139 | 0.0096 | 0.0113 | 0.0088 |
0.005
| 0.0043 | 0.0034 | 0.0078 | 0.0044 | 0.0055 | 0.0034 |
0.001
| 0.0011 | 0.0006 | 0.0015 | 0.0005 | 0.0014 | 0.0008 |
0.0005
| 0.0009 | 0.0003 | 0.0006 | 0.0004 | 0.0006 | 0.0003 |
Mean
| -0.015 | -0.027 | 0.059 | -0.007 | 0.041 | -0.026 |
SD
| 1.001 | 1.007 | 1.019 | 1.017 | 1.004 | 1.008 |
p-value
f
| 0.067 | 0.0037 | < 0.0001 | 0.246 | < 0.0001 | 0.0049 |
- Observed versus expected distributions of linkage test statistics under varying conditions of disease allele and/or population heterogeneity in marker allele frequencies, based on 10,000 simulations of 100 families with the following configuration: 2 affected sibs, both sampled, and 2 unaffected sibs, both sampled, disease locus unlinked to markers (null model).
-
emean multipoint paired test; fp-value of test that mean does not equal 0; gtwo populations modeled in an 80%/20% mixture: 1) marker allele frequencies for all markers [0.25,0.25,0.25,0.25], unlinked disease allele 0.0035; 2) marker alleles [0.25,0.25,0.25,0.25], unlinked disease allele 0.001; htwo populations modeled in an 80%/20% mixture: 1) marker allele frequencies for all markers [0.25,0.25,0.25,0.25], unlinked disease allele 0.003; 2) marker alleles [0.4,0.3,0.2,0.1], unlinked disease allele 0.003; itwo populations modeled in an 80%/20% mixture: 1) marker allele frequencies for all markers [0.25,0.25,0.25,0.25], unlinked disease allele 0.0035; 2) marker alleles [0.4,0.3,0.2,0.1], unlinked disease allele 0.001.
