Skip to main content

Table 3 Simulation results under varied conditions of heterogeneity

From: Design considerations in a sib-pair study of linkage for susceptibility loci in cancer

  Heterogeneity Model
  Disease Allele Onlyg Markers Onlyh Disease and Markersi
One-Tailed p Zc Zp Zc Zp Zc Zp
0.1 0.0966 0.0939 0.1153 0.1022 0.1038 0.0951
0.05 0.0471 0.0426 0.0626 0.0515 0.0527 0.0442
0.01 0.0087 0.0084 0.0139 0.0096 0.0113 0.0088
0.005 0.0043 0.0034 0.0078 0.0044 0.0055 0.0034
0.001 0.0011 0.0006 0.0015 0.0005 0.0014 0.0008
0.0005 0.0009 0.0003 0.0006 0.0004 0.0006 0.0003
Mean -0.015 -0.027 0.059 -0.007 0.041 -0.026
SD 1.001 1.007 1.019 1.017 1.004 1.008
p-value f 0.067 0.0037 < 0.0001 0.246 < 0.0001 0.0049
  1. Observed versus expected distributions of linkage test statistics under varying conditions of disease allele and/or population heterogeneity in marker allele frequencies, based on 10,000 simulations of 100 families with the following configuration: 2 affected sibs, both sampled, and 2 unaffected sibs, both sampled, disease locus unlinked to markers (null model).
  2. emean multipoint paired test; fp-value of test that mean does not equal 0; gtwo populations modeled in an 80%/20% mixture: 1) marker allele frequencies for all markers [0.25,0.25,0.25,0.25], unlinked disease allele 0.0035; 2) marker alleles [0.25,0.25,0.25,0.25], unlinked disease allele 0.001; htwo populations modeled in an 80%/20% mixture: 1) marker allele frequencies for all markers [0.25,0.25,0.25,0.25], unlinked disease allele 0.003; 2) marker alleles [0.4,0.3,0.2,0.1], unlinked disease allele 0.003; itwo populations modeled in an 80%/20% mixture: 1) marker allele frequencies for all markers [0.25,0.25,0.25,0.25], unlinked disease allele 0.0035; 2) marker alleles [0.4,0.3,0.2,0.1], unlinked disease allele 0.001.