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Table 2 Simulation results

From: Design considerations in a sib-pair study of linkage for susceptibility loci in cancer

 

Statistic

One-Tailed p

Zc a

Zd b

Zp c

Zmc d

Zmp e

0.1

0.0987

0.1169

0.0966

0.0663

0.0971

0.05

0.0505

0.0637

0.0451

0.0317

0.0473

0.01

0.0107

0.0170

0.0094

0.0028

0.0039

0.005

0.0053

0.0097

0.0048

0.0003

0.0010

0.001

0.0013

0.0022

0.0008

0.0001

0.0006

0.0005

0.0010

0.0013

0.0004

0.0001

0.0000

Mean

-0.005

-0.004

-0.0175

-0.246

-0.036

SD

1.002

1.087

1.004

1.015

1.016

p-value f

0.309

0.356

0.041

< 0.0001

0.0002

  1. Observed versus expected distributions of linkage test statistics, based on 10,000 simulations of 100 families with the following configuration: 2 affected sibs, both sampled, and 2 unaffected sibs, both sampled, disease locus unlinked to markers (null model).
  2. amean concordant test; bmean discordant (unpaired) test; cmean paired test; dmean multipoint concordant test (10 cM spacing between markers); emean multipoint paired test; fp-value of test that mean does not equal 0;
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BMC Medical Genetics

ISSN: 1471-2350

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