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Table 1 Parameters employed in simulations

From: Design considerations in a sib-pair study of linkage for susceptibility loci in cancer

Parameter Simulated Values  
Families 500  
Affected Sibs Total 2, 3  
Affected Sibs Genotyped 1, 2, 3  
Unaffected Sibs Total 0, 1, 2, 3  
Unaffected Sibs Genotyped 0, 1, 2, 3  
Parents Genotyped 0, 1, 2  
Offspring Proxies 0, 1, 2  
Screen for Unlinked Syndrome No, Yes  
Population Disease Prevalence 0.02, 0.05  
Mode of Inheritance Autosomal Dominant  
Relative Risk to Carriers 10, 20  
Number of Disease Loci 0, 1, 2  
Disease Allele Frequency 0.003, 0.005, 0.01  
Marker Spacing (cM) 5.0, 10.0  
Admixture Models: Population 1 (80%) Population 2 (20%)
Marker Allele Frequencies [0.25, 0.25, 0.25, 0.25] [0.1, 0.2, 0.3, 0.4]
Disease Allele Frequencies [0.00325, 0.0035] [0.002, 0.001]
  1. Parameters and parameter values employed in the simulations