Table 1 Parameters employed in simulations

Families

500

Affected Sibs Total

2, 3

Affected Sibs Genotyped

1, 2, 3

Unaffected Sibs Total

0, 1, 2, 3

Unaffected Sibs Genotyped

0, 1, 2, 3

Parents Genotyped

0, 1, 2

Offspring Proxies

0, 1, 2

Screen for Unlinked Syndrome

No, Yes

Population Disease Prevalence

0.02, 0.05

Mode of Inheritance

Autosomal Dominant

Relative Risk to Carriers

10, 20

Number of Disease Loci

0, 1, 2

Disease Allele Frequency

0.003, 0.005, 0.01

Marker Spacing (cM)

5.0, 10.0

Admixture Models:

Population 1 (80%)

Population 2 (20%)

Marker Allele Frequencies

[0.25, 0.25, 0.25, 0.25]

[0.1, 0.2, 0.3, 0.4]

Disease Allele Frequencies

[0.00325, 0.0035]

[0.002, 0.001]