Detection of Catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE

Table 1 Catalase SNP (rs 1000179) in cases with SLE and normal controls and pedigree disequilibrium test

We have used 48 multigenerational, multiplex families for our family-based association analysis using the PDT program [19]. The test retains a key property of the "transmission disequilibrium test (TDT)", in that it is valid even when there is population substructure or stratification. The PDT program performs both allele-specific and genotype-specific LD analysis of individual markers. T-test was used to assess the significance of for mean differences in general characteristics between SLE and normal subjects. We did not find a single individual in our pedigrees that presented with a T/T genotype, though the reported T/T genotype in African American population is 3.2%.

ISSN: 1471-2350