Analytical approaches to detect maternal/fetal genotype incompatibilities that increase risk of pre-eclampsia

BMC Medical Genetics

Table 2 Biologically plausible models of incompatibility

Model		Maternal Genotype (g_m)	Offspring Genotype (g_off)	Scenario
1	I₁	AA	Aa	Symmetric Incompatibility: offspring has any allele that mother does not
	I₄	aa	Aa
2	I₂	Aa	AA	Gestational Drive: Mother has an allele that offspring does not
	I₃	Aa	aa
3	I₁	AA	Aa	Asymmetric Incompatibility: offspring has a particular allele ("a") that mother does not
4	I₂	Aa	AA	Mother-offspring pair possess 3 copies of the "A" allele
	I₁	AA	Aa
5	I₁	AA	Aa	Any difference between maternal and offspring genotypes will result in disease
	I₂	Aa	AA
	I₃	Aa	aa
	I₄	aa	Aa
6	I₃	Aa	aa	Mother-offspring pair possess 3 copies of the "a" allele
	I₄	aa	Aa

ISSN: 1471-2350