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Table 2 Candidate gene polymorphisms and type 2 diabetes risk in Khatri Sikhs; comparing NGT vs. T2D

From: Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTOvariants confer a significant risk

       ODDS RATIO (ORs*)
GENE/SNP CHROMO SOME POSITIONψ GENOTYPE NGT (%) T2D (%) CO-DOMINANT DOMINANT RECESSIVE
       OR (95% CI) OR (95% CI) OR (95% CI)
PPARG2 3 12336825       
rs 1801282    CC 286 (76.5) 414 (80.4) CC vs. CG, GG CC vs. CG+GG CC+CG vs. GG
    CG 78 (20.8) 99 (19.2) 0.96 (0.68–1.35) 0.84 (0.61–1.17) 0.12 (0.03–0.52)
    GG 10 (2.7) 2 (0.4) 0.11 (0.03–0.51)   
    Allele C 0.87 0.90 CG; p = 0.824 p = 0.300 p = 0.005
    Allele G 0.13 0.10 GG; p = 0.005   
IGF2BP2 3 186994381       
rs 4402960    GG 150 (38.9) 160 (31.1) GG vs. GT, TT GG vs. GT+TT GG+GT vs. TT
    GT 173 (44.8) 262 (51.0) 1.36 (1.01–1.84) 1.37 (1.04–1.82) 1.18 (0.82–1.68)
    TT 63 (16.3) 92 (17.9) 1.42 (0.95–2.10)   
    Allele G 0.61 0.57 GT; p = 0.041 p = 0.027 p = 0.372
    Allele T 0.39 0.43 TT; p = 0.087   
CDK5 6 20769229       
rs 7754840    GG 203 (55.2) 281 (53.7) GG vs. CG, CC GG vs. CG+CC GG+CG vs. CC
    CG 134 (36.4) 196 (37.5) 1.04 (0.78–1.40) 1.06 (0.80–1.37) 1.10 (0.68–1.78)
    CC 31(8.4) 46 (8.8) 1.12 (0.68–1.83)   
    Allele G 0.73 0.55 CG; p = 0.771 p = 0.688 p = 0.692
    Allele C 0.27 0.45 CC; p = 0.655   
SLC30A8 8 118253964       
rs 13266634    CC 188 (53.9) 290 (54.5) CC vs. CT, TT CC vs. CT+TT CC+CT vs. TT
    CT 135 (38.7) 195 (36.6) 0.95 (0.71–1.27) 0.99 (0.75–1.30) 1.23 (0.74–2.02)
    TT 26 (7.4) 47 (8.8) 1.21 (0.72–2.04)   
    Allele C 0.73 0.73 CT; p = 0.718 p = 0.946 p = 0.424
    Allele T 0.27 0.27 TT; p = 0.468   
CDKN2A 9 22124094       
rs 10811661    TT 232 (78.6) 427 (82.7) TT vs. CT, CC TT vs. CT+CC TT+CT vs. CC
    CT 61 (20.6) 87 (16.9) 0.85 (0.58–1.23) 0.84 (0.58–1.21) 0.54 (0.08–3.93)
    CC 2 (0.7) 2 (0.4) 0.51 (0.07–3.73)   
    Allele T 0.89 0.91 CT; p = 0.386 p = 0.343 p = 0.545
    Allele C 0.11 0.09 CC p = 0.511   
HHEX 10 94452862       
rs 1111875    TT 120 (32.7) 154 (30.0) TT vs. CT, CC TT vs. CT+CC TT+CT vs. CC
    CT 166 (45.2) 242 (47.0) 1.28 (1.02–1.90) 1.22 (0.93–1.60) 1.10 (0.82–1.47)
    CC 81 (22.1) 118 (23.0) 1.16 (0.80–1.67)   
    Allele T 0.55 0.54 CT; p = 0.107 p = 0.147 p = 0.529
    Allele C 0.45 0.46 CC; p = 0.438   
TCF7L2 10 114798062       
rs 10885409    TT 118 (31.7) 112 (21.8) TT vs. TC, CC TT vs. TC+CC TT+TC vs. CC
    CT 169 (45.4) 257 (50.0) 1.59 (1.14–2.23) 1.64 (1.20–2.24) 0.76 (0.55–1.03)
    CC 85 (22.8) 145 (28.2) 1.72 (1.18–2.53)   
    Allele T 0.54 0.47 TC; p = 0.006 p = 0.001 p = 0.078
    Allele C 0.46 0.53 CC; p = 0.003   
KCNJ11 11 17366148       
rs 5219    CC 148 (39.6) 226 (42.5) CC vs. CT. TT CC vs. CT+TT CC+CT vs. TT
    CT 169 (45.2) 247 (46.4) 0.97 (0.73–1.30) 0.90 (0.69–1.19) 0.71 (0.48–1.06)
    TT 57 (15.2) 59 (11.1) 0.70 (0.46–1.08)   
    Allele C 0.66 0.62 CT; p = 0.835 p = 0.458 p = 0.091
    Allele T 0.34 0.38 TT; p = 0.110   
FTO 16 52378028       
rs 9939609    TT 175 (49.6) 205 (39.9) TT vs. AT, AA TT vs. AT+AA TT+AT vs. AA
    AT 137 (38.8) 244 (47.6) 1.51 (1.30–3.03) 1.46 (1.11–1.93) 1.08 (0.71 – 1.64)
    AA 41 (11.6) 64 (12.5) 1.32 (0.84–1.93)   
    Allele T 0.69 0.64 AT; p = 0.006 p = 0.007 p = 0.737
    Allele A 0.31 0.36 AA; p = 0.227   
  1. *ORs were adjusted for age, sex, and BMI; ψ Position of SNPs on chromosome has been taken from NCBI (Genome Build 36.3)