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Table 2 Candidate gene polymorphisms and type 2 diabetes risk in Khatri Sikhs; comparing NGT vs. T2D

From: Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTOvariants confer a significant risk

      

ODDS RATIO (ORs*)

GENE/SNP

CHROMO SOME

POSITIONψ

GENOTYPE

NGT (%)

T2D (%)

CO-DOMINANT

DOMINANT

RECESSIVE

      

OR (95% CI)

OR (95% CI)

OR (95% CI)

PPARG2

3

12336825

      

rs 1801282

  

CC

286 (76.5)

414 (80.4)

CC vs. CG, GG

CC vs. CG+GG

CC+CG vs. GG

   

CG

78 (20.8)

99 (19.2)

0.96 (0.68–1.35)

0.84 (0.61–1.17)

0.12 (0.03–0.52)

   

GG

10 (2.7)

2 (0.4)

0.11 (0.03–0.51)

  
   

Allele C

0.87

0.90

CG; p = 0.824

p = 0.300

p = 0.005

   

Allele G

0.13

0.10

GG; p = 0.005

  

IGF2BP2

3

186994381

      

rs 4402960

  

GG

150 (38.9)

160 (31.1)

GG vs. GT, TT

GG vs. GT+TT

GG+GT vs. TT

   

GT

173 (44.8)

262 (51.0)

1.36 (1.01–1.84)

1.37 (1.04–1.82)

1.18 (0.82–1.68)

   

TT

63 (16.3)

92 (17.9)

1.42 (0.95–2.10)

  
   

Allele G

0.61

0.57

GT; p = 0.041

p = 0.027

p = 0.372

   

Allele T

0.39

0.43

TT; p = 0.087

  

CDK5

6

20769229

      

rs 7754840

  

GG

203 (55.2)

281 (53.7)

GG vs. CG, CC

GG vs. CG+CC

GG+CG vs. CC

   

CG

134 (36.4)

196 (37.5)

1.04 (0.78–1.40)

1.06 (0.80–1.37)

1.10 (0.68–1.78)

   

CC

31(8.4)

46 (8.8)

1.12 (0.68–1.83)

  
   

Allele G

0.73

0.55

CG; p = 0.771

p = 0.688

p = 0.692

   

Allele C

0.27

0.45

CC; p = 0.655

  

SLC30A8

8

118253964

      

rs 13266634

  

CC

188 (53.9)

290 (54.5)

CC vs. CT, TT

CC vs. CT+TT

CC+CT vs. TT

   

CT

135 (38.7)

195 (36.6)

0.95 (0.71–1.27)

0.99 (0.75–1.30)

1.23 (0.74–2.02)

   

TT

26 (7.4)

47 (8.8)

1.21 (0.72–2.04)

  
   

Allele C

0.73

0.73

CT; p = 0.718

p = 0.946

p = 0.424

   

Allele T

0.27

0.27

TT; p = 0.468

  

CDKN2A

9

22124094

      

rs 10811661

  

TT

232 (78.6)

427 (82.7)

TT vs. CT, CC

TT vs. CT+CC

TT+CT vs. CC

   

CT

61 (20.6)

87 (16.9)

0.85 (0.58–1.23)

0.84 (0.58–1.21)

0.54 (0.08–3.93)

   

CC

2 (0.7)

2 (0.4)

0.51 (0.07–3.73)

  
   

Allele T

0.89

0.91

CT; p = 0.386

p = 0.343

p = 0.545

   

Allele C

0.11

0.09

CC p = 0.511

  

HHEX

10

94452862

      

rs 1111875

  

TT

120 (32.7)

154 (30.0)

TT vs. CT, CC

TT vs. CT+CC

TT+CT vs. CC

   

CT

166 (45.2)

242 (47.0)

1.28 (1.02–1.90)

1.22 (0.93–1.60)

1.10 (0.82–1.47)

   

CC

81 (22.1)

118 (23.0)

1.16 (0.80–1.67)

  
   

Allele T

0.55

0.54

CT; p = 0.107

p = 0.147

p = 0.529

   

Allele C

0.45

0.46

CC; p = 0.438

  

TCF7L2

10

114798062

      

rs 10885409

  

TT

118 (31.7)

112 (21.8)

TT vs. TC, CC

TT vs. TC+CC

TT+TC vs. CC

   

CT

169 (45.4)

257 (50.0)

1.59 (1.14–2.23)

1.64 (1.20–2.24)

0.76 (0.55–1.03)

   

CC

85 (22.8)

145 (28.2)

1.72 (1.18–2.53)

  
   

Allele T

0.54

0.47

TC; p = 0.006

p = 0.001

p = 0.078

   

Allele C

0.46

0.53

CC; p = 0.003

  

KCNJ11

11

17366148

      

rs 5219

  

CC

148 (39.6)

226 (42.5)

CC vs. CT. TT

CC vs. CT+TT

CC+CT vs. TT

   

CT

169 (45.2)

247 (46.4)

0.97 (0.73–1.30)

0.90 (0.69–1.19)

0.71 (0.48–1.06)

   

TT

57 (15.2)

59 (11.1)

0.70 (0.46–1.08)

  
   

Allele C

0.66

0.62

CT; p = 0.835

p = 0.458

p = 0.091

   

Allele T

0.34

0.38

TT; p = 0.110

  

FTO

16

52378028

      

rs 9939609

  

TT

175 (49.6)

205 (39.9)

TT vs. AT, AA

TT vs. AT+AA

TT+AT vs. AA

   

AT

137 (38.8)

244 (47.6)

1.51 (1.30–3.03)

1.46 (1.11–1.93)

1.08 (0.71 – 1.64)

   

AA

41 (11.6)

64 (12.5)

1.32 (0.84–1.93)

  
   

Allele T

0.69

0.64

AT; p = 0.006

p = 0.007

p = 0.737

   

Allele A

0.31

0.36

AA; p = 0.227

  
  1. *ORs were adjusted for age, sex, and BMI; ψ Position of SNPs on chromosome has been taken from NCBI (Genome Build 36.3)
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