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Table 1 Relatedness estimates.

From: Novel de novo BRCA2mutation in a patient with a family history of breast cancer

Individual

Individual

k0

k1

k2

Relationship

1

2

0.23

0.49

0.28

full siblings

1

3

0.01

0.99

0.00

parent offspring

1

4

0.01

0.99

0.00

parent offspring

2

3

0.01

0.98

0.01

parent offspring

2

4

0.01

0.99

0.01

parent offspring

3

4

0.98

0.02

0.00

unrelated

  1. Relationship was infered by estimating the pairwise identical by descent (IBD) sharing as described in [17]. k0 is the probality that pairs of individuals at a random loci share no allele IBD, k1 the probality that pairs of individuals at a random loci share one allele IBD, and k2 the probality that pairs of individuals at a random loci share two allele IBD. The expected relatedness for full siblings is k0 = 0.25, k1 = 0.5, k2 = 0.25, for parent offspring k0 = 0, k1 = 1, k2 = 0, and for unrelated k0 = 1, k1 = 0, k2 = 0. The individual number is indicated in figure 1.