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Table 3 Results of mitochondrial haplogroup association testing with ischemic stroke risk.

From: Mitochondrial haplogroup H1 is protective for ischemic stroke in Portuguese patients

 

Number of Individuals (%)

Chi-square Test

Logistic Regression Model

Haplogroup

Controls

Patients

P-value

OR [95% CI]

P-value

OR [95% CI]

H

118 (23.6)

116 (21.7)

0.454

 

0.432

 

H1

125 (25.1)

91 (17.0)

0.001

0.61 [0.45–0.83]

0.007

0.57 [0.38–0.85]

V

13 (2.6)

12 (2.2)

0.707

 

0.861

 

pre-HV/HV

8 (1.6)

26 (4.9)

0.003

3.14 [1.41–7.01]

0.008

4.68 [1.51–14.54]

J

9 (1.8)

9 (1.7)

0.883

 

0.122

 

J1b

23 (4.6)

24 (4.5)

0.928

 

0.862

 

T

56 (11.2)

65 (12.2)

0.637

 

0.249

 

U

6 (1.2)

18 (3.4)

0.021

2.87 [1.13–7.28]

0.038

4.01 [1.08–14.90]

U4

13 (2.6)

16 (3.0)

0.705

 

0.286

 

U5

24 (4.0)

34 (6.3)

0.278

 

0.048

2.17 [1.01–4.67]

U6a

10 (2.0)

10 (1.9)

0.877

 

0.71

 

K1

27 (5.4)

28 (5.2)

0.903

 

0.184

 

I

10 (2.0)

11 (2.1)

0.950

 

0.500

 

X2b

7 (1.4)

9 (1.7)

0.714

 

0.789

 

W

6 (1.2)

11 (2.1)

0.279

 

0.394

 

L

25 (5.0)

34 (6.4)

0.348

 

0.913

 

Other*

19 (3.8)

20 (3.7)

-

 

-

 
  1. Significant uncorrected P-values (< 0.05) are highlighted in bold. Crude and adjusted odds ratios (OR) and 95% confidence intervals (CI) are shown only for significantly associated haplogroups.
  2. *Given that the "Other" class includes an assortment of lineages not phylogeneticaly correlated, association tests were not performed.