Association between LRP5 polymorphism and bone mineral density: a Bayesian meta-analysis

BMC Medical Genetics

Table 1 Characteristics of individual studies

Study	Study design	Ethnicity	Age (mean or range)	BMD measurement	Sex	Frequency of A1330V genotypes			Frequency of AA
						AA	AV	VV
Koh, 2004 [23]	CS	Asian	25.6	LS + FN	Men	161	51	7	0.74
Mizuguchi, 2004 [37]	CC	Asian	54.2	LS	Women	129	114	11	0.51
Koller, 2005 [24]	CS	Caucasian	20 – 50	LS + FN	Women	833	416	52	0.64
Zhang, 2005 [38]	C	Asian	60.1	LS + FN	Women	440	192	15	0.68
van Meurs, 2006 [39]	C	Caucasian	≥ 55	LS + FN	Men^a	895	643	54	0.56
		Caucasian			Women	2766	939	76	0.73
Ezura, 2007 [18]	CS	Asian	64.6	LS	Women	178	174	35	0.46
Saarinen, 2007 [40]	CS	Caucasian	18 – 21	LS + FN	Men	215	20		0.91
Giroux, 2007 [20]	CS	Caucasian	53.3	LS + FN	Women	1452	622		0.70
Grundberg, 2007 [21]	CS	Caucasian	69 – 81	LS + FN	Men	2114	620	33	0.76
	CS	Asian	> 65	LS + FN	Men	1067	487	70	0.66
	CS	Caucasian	18 – 20	LS + FN	Men	806	216	23	0.77
Brixen, 2007 [36]	CS	Caucasian	20 – 30	LS	Men	589	170	20	0.76

CS = cross-sectional study, CC = case-control study, C = cohort study; LS = lumbar spine, FN = femoral neck.
^aThe distribution of genotypes was not consistent with the Hardy-Weinberg's equilibrium law (p < 0.0001).

ISSN: 1471-2350