Skip to main content

Table 1 Single SNP Analysis

From: The NEI/NCBI dbGAP database: Genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration

SNP

Gene*

Location*

2 × 2 McNemar's test p-value

3 × 3 McNemar's test p-value

Likelihood Ratio Test p-value

Odds Ratio (95% C.I.) of most likely mode of inheritance

Likelihood Ratio Test Model

rs800292

CFH

1q32

0.0005

1.6766E-05

0.0020

0.295(0.126–0.693)

Additive

rs572515

CFH

1q32

1.1422E-06

2.1771E-09

7.0012E-07

4.619(2.288–9.326)

Additive

rs7529589

CFH

1q32

0.0003

1.6852E-05

1.2034E-05

8.403(2.670–26.442)

Recessive

rs1061170

CFH

1q32

0.0002

3.9821E-05

1.9045E-05

7.382(2.495–21.838)

Recessive

rs12038333

CFH

1q32

0.0001

1.7989E-06

8.3182E-06

3.151(1.707–5.819)

Recessive

rs203674

CFH

1q32

5.7447E-06

5.0608E-08

4.3995E-06

3.914(2.020–7.585)

Additive

rs10801575

~CFH

~1q32

0.0304

0.0315

0.0108

0.370(0.174–0.785)

Dominant

rs1853883

CFHR4

1q32

0.0001

6.9750E-06

0.0003

2.687(1.519–4.751)

Additive

rs3790414

CFHR2

1q31-q32.1

0.0018

0.0002

0.0137

0.424(0.206–0.876)

Additive

rs1759016

CFHR5

1q22-q23

0.0092

0.0037

0.0092

0.465(0.262–0.827)

Additive

rs10922152

CFHR5

1q22-q23

0.0007

0.0001

0.0014

0.434(0.258–0.730)

Additive

rs10922153

CFHR5

1q22-q23

0.0002

1.0290E-05

0.0004

0.389(0.224–0.677)

Additive

rs6663083

?

1q31-1q32

0.0003

1.6704E-05

0.0008

0.419(0.248–0.707)

Additive

rs2990510

F13B

1q31-q32.1

0.0438

0.0395

0.1003

2.462(0.801–7.571)

Recessive

rs6003

F13B

1q31-q32.1

0.0153

0.0022

0.0025

0.162(0.041–0.631)

Additive

rs1412632

?

1q31-1q32

0.0153

0.0022

0.0030

0.165(0.042–0.645)

Additive

rs1412631

?

1q31-1q32

0.0098

0.0005

0.0013

0.110(0.022–0.557)

Additive

rs12677

ASPM

1q31

0.0098

0.0005

0.0019

0.127(0.026–0.609)

Additive

rs4915337

ASPM

1q31

0.0614

0.0233

0.0067

0.182(0.045–0.740)

Additive

rs1888991

ASPM

1q31

0.0244

0.0051

0.0044

0.175(0.044–0.696)

Additive

rs6677082

ASPM

1q31

0.0244

0.0051

0.0048

0.175(0.044–0.695)

Additive

rs6656448

ZBTB41

1q31.3

0.0218

0.0054

0.0042

0.209(0.063–0.694)

Additive

rs9288410

MAP2

2q34-q35

0.5563

0.3721

0.0294

1.923(0.885–4.179)

Recessive

rs304039

ITPR1

3p26-p25

0.6774

0.7070

0.1035

1.943(0.858–4.396)

Recessive

rs304041

ITPR1

3p26-p25

0.5896

0.4206

0.1035

1.943(0.858–4.396)

Recessive

rs1038639

ITPR1

3p26-p25

1.0000

0.9062

0.4345

0.731(0.332–1.610)

Dominant

rs1447338

?

4q34-4q35

0.5419

0.4856

0.2949

1.350(0.730–2.497)

Additive

rs7090030

ADD3

10q24.2-q24.3

1.0000

1.0000

0.5834

0.485(0.035–6.710)

Additive

rs11194995

ADD3

10q24.2-q24.3

1.0000

1.0000

0.5834

0.485(0.035–6.710)

Additive

rs11194996

ADD3

10q24.2-q24.3

1.0000

1.0000

0.9217

0.881(0.071–10.862)

Additive

rs11195001

ADD3

10q24.2-q24.3

1.0000

1.0000

1.0000

0.485(0.035–6.715)

Additive

rs2014307

PLEKHA1/HTRA1

10q26

6.6872E-06

8.1056E-07

3.7092E-05

0.240(0.111–0.520)

Additive

rs949252

GPR152

11q13.1

0.4795

0.4795

0.1979

2.006(0.115–35.135)

Dominant

rs7124630

TMEM134

11q13.1

0.4795

0.0000

0.3864

1.004E-07(0.000-Inf)

Additive

rs11575221

STAT2

12q13-12q14

1.0000

1.0000

0.4358

2.740(0.204–36.835)

Additive

  1. Abbreviations: SNP, single nucleotide polymorphism; C.I., confidence interval.
  2. * Gene and location of each SNP determined using ENSEMBL [15].