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Table 1 Single SNP Analysis

From: The NEI/NCBI dbGAP database: Genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration

SNP Gene* Location* 2 × 2 McNemar's test p-value 3 × 3 McNemar's test p-value Likelihood Ratio Test p-value Odds Ratio (95% C.I.) of most likely mode of inheritance Likelihood Ratio Test Model
rs800292 CFH 1q32 0.0005 1.6766E-05 0.0020 0.295(0.126–0.693) Additive
rs572515 CFH 1q32 1.1422E-06 2.1771E-09 7.0012E-07 4.619(2.288–9.326) Additive
rs7529589 CFH 1q32 0.0003 1.6852E-05 1.2034E-05 8.403(2.670–26.442) Recessive
rs1061170 CFH 1q32 0.0002 3.9821E-05 1.9045E-05 7.382(2.495–21.838) Recessive
rs12038333 CFH 1q32 0.0001 1.7989E-06 8.3182E-06 3.151(1.707–5.819) Recessive
rs203674 CFH 1q32 5.7447E-06 5.0608E-08 4.3995E-06 3.914(2.020–7.585) Additive
rs10801575 ~CFH ~1q32 0.0304 0.0315 0.0108 0.370(0.174–0.785) Dominant
rs1853883 CFHR4 1q32 0.0001 6.9750E-06 0.0003 2.687(1.519–4.751) Additive
rs3790414 CFHR2 1q31-q32.1 0.0018 0.0002 0.0137 0.424(0.206–0.876) Additive
rs1759016 CFHR5 1q22-q23 0.0092 0.0037 0.0092 0.465(0.262–0.827) Additive
rs10922152 CFHR5 1q22-q23 0.0007 0.0001 0.0014 0.434(0.258–0.730) Additive
rs10922153 CFHR5 1q22-q23 0.0002 1.0290E-05 0.0004 0.389(0.224–0.677) Additive
rs6663083 ? 1q31-1q32 0.0003 1.6704E-05 0.0008 0.419(0.248–0.707) Additive
rs2990510 F13B 1q31-q32.1 0.0438 0.0395 0.1003 2.462(0.801–7.571) Recessive
rs6003 F13B 1q31-q32.1 0.0153 0.0022 0.0025 0.162(0.041–0.631) Additive
rs1412632 ? 1q31-1q32 0.0153 0.0022 0.0030 0.165(0.042–0.645) Additive
rs1412631 ? 1q31-1q32 0.0098 0.0005 0.0013 0.110(0.022–0.557) Additive
rs12677 ASPM 1q31 0.0098 0.0005 0.0019 0.127(0.026–0.609) Additive
rs4915337 ASPM 1q31 0.0614 0.0233 0.0067 0.182(0.045–0.740) Additive
rs1888991 ASPM 1q31 0.0244 0.0051 0.0044 0.175(0.044–0.696) Additive
rs6677082 ASPM 1q31 0.0244 0.0051 0.0048 0.175(0.044–0.695) Additive
rs6656448 ZBTB41 1q31.3 0.0218 0.0054 0.0042 0.209(0.063–0.694) Additive
rs9288410 MAP2 2q34-q35 0.5563 0.3721 0.0294 1.923(0.885–4.179) Recessive
rs304039 ITPR1 3p26-p25 0.6774 0.7070 0.1035 1.943(0.858–4.396) Recessive
rs304041 ITPR1 3p26-p25 0.5896 0.4206 0.1035 1.943(0.858–4.396) Recessive
rs1038639 ITPR1 3p26-p25 1.0000 0.9062 0.4345 0.731(0.332–1.610) Dominant
rs1447338 ? 4q34-4q35 0.5419 0.4856 0.2949 1.350(0.730–2.497) Additive
rs7090030 ADD3 10q24.2-q24.3 1.0000 1.0000 0.5834 0.485(0.035–6.710) Additive
rs11194995 ADD3 10q24.2-q24.3 1.0000 1.0000 0.5834 0.485(0.035–6.710) Additive
rs11194996 ADD3 10q24.2-q24.3 1.0000 1.0000 0.9217 0.881(0.071–10.862) Additive
rs11195001 ADD3 10q24.2-q24.3 1.0000 1.0000 1.0000 0.485(0.035–6.715) Additive
rs2014307 PLEKHA1/HTRA1 10q26 6.6872E-06 8.1056E-07 3.7092E-05 0.240(0.111–0.520) Additive
rs949252 GPR152 11q13.1 0.4795 0.4795 0.1979 2.006(0.115–35.135) Dominant
rs7124630 TMEM134 11q13.1 0.4795 0.0000 0.3864 1.004E-07(0.000-Inf) Additive
rs11575221 STAT2 12q13-12q14 1.0000 1.0000 0.4358 2.740(0.204–36.835) Additive
  1. Abbreviations: SNP, single nucleotide polymorphism; C.I., confidence interval.
  2. * Gene and location of each SNP determined using ENSEMBL [15].