Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies

Table 2 Minor allele frequencies for all SNPs genotyped in 1,345 FHS and 11,447 white ARIC participants

			n		MAF
SNP	gene	location	FHS	ARIC white	FHS	ARIC white
*Selected for low p-value only*
rs4553158	MIER1	chr1:67148467	1,219	10,685	0.13 (G)	0.17 (G)
rs6831700	WDR19	chr4:39079530	1,273	10,808	0.34 (G)	0.33 (G)
rs2419912	(BC047601)	chr5:157777113	1,341	10,817	0.49 (C)	0.46 (C)
rs2228210	HIVEP1	chr6:12230160	1,252	10,782	0.29 (G)	0.36 (G)
rs10509132	ANK3	chr10:61995671	1,223	10,783	0.45 (G)	0.48 (G)
rs1613631	KRT84	chr12:51062202	1,330	10,782	0.20 (G)	0.20 (G)
rs6495446	MTHFS	chr15:77942037	1,328	10,816	0.24 (T)	0.27 (T)
rs2827732	gene desert	chr21:23107838	1,344	10,768	0.19 (A)	0.16 (A)
*Selected as a candidate*
rs2061063	FRAS1	chr4:79591766	1,322	10,747	0.33 (G)	0.35 (G)
rs4835136	NR3C2	chr4:149627601	1,334	10,990	0.36 (T)	0.37 (T)
rs1743955	SGK1	chr6:134562589	1,299	10,763	0.42 (T)	0.39 (T)
rs4148686	CFTR	chr7:116728468	1,225	10,795	0.17 (G)	0.20 (G)
rs3779748	EYA1	chr8:72410728	1,342	10,789	0.32 (C)	0.33 (C)
rs1455177	BC047388	chr9:3782613	1,337	10,434	0.45 (G)	0.45 (G)
rs10520688	IQGAP1	chr15:88752520	1,331	10,814	0.15 (G)	0.14 (G)
rs2839235	PCNT	chr21:46625020	1,300	10,799	0.14 (C)	0.13 (C)

To facilitate interpretation, alleles were transferred to the strand typed in ARIC if they were typed on the opposite strand in FHS. The sample size n presented here is for all successfully genotyped individuals irrespective of whether all covariates for regression analyses were available. Abbreviations: SNPs: single nucleotide polymorphisms, n: sample size, MAF: minor allele frequency.

ISSN: 1471-2350