Table 3 Clinical features of female T1D patients with or without DN according to genotypes of SNP rs5498 E469K

Genotypes

AA

AG

GG

AA

AG

GG

Age (yrs)

39 ± 8

39 ± 9

40 ± 9

43 ± 7

42 ± 8

43 ± 7

0.411

Duration (yrs)

26 ± 7

26 ± 8

27 ± 8

30 ± 9

31 ± 8

33 ± 8

0.211

HbA1c (%)

7.72 ± 1.27

7.50 ± 1.12

7.33 ± 0.89

7.54 ± 2.14

7.26 ± 1.99

7.20 ± 2.15

0.475

BMI (kg/m²)

25.6 ± 4.9

25.8 ± 4.6

25.1 ± 4.2

26.1 ± 6.3

25.2 ± 6.1

24.9 ± 4.9

0.308

Cystatin (mg/L)

0.79 ± 0.17

0.81 ± 0.14

0.75 ± 0.12

2.20 ± 1.86

2.38 ± 1.92

2.18 ± 1.64

0.690

Creatinine (mg/dL)

0.82 ± 0.14

0.85 ± 0.14

0.81 ± 0.13

2.02 ± 2.29

2.11 ± 1.90

2.01 ± 1.96

0.932

Cholesterol (mg/dL)

185.9 ± 29.3

190.2 ± 31.8

189.1 ± 33.0

185.2 ± 45.8

193.2 ± 45.0

189.8 ± 47.7

0.424

HDL (mg/dL)

63.8 ± 15.1

65.0 ± 15.6

65.0 ± 15.8

58.5 ± 17.4

59.4 ± 20.0

58.4 ± 17.3

0.904

SBP (mmHg)

116 ± 13

116 ± 11

117 ± 13

130 ± 21

132 ± 20

128 ± 20

0.472

DBP (mmHg)

71 ± 8

69 ± 7

70 ± 7

71 ± 11

74 ± 11

71 ± 11

0.063