Table 2 Association of SNPs rs1799969 G241R and rs5498 E469K in the ICAM-1 gene between T1D with DN and T1D without DN
SNP ID | Position* | SNP type | Groups | Genotypes (%) | MAF | Heterozygous | Allele positivity | ||
|---|---|---|---|---|---|---|---|---|---|
rs1799969 | Exon 4 | R241G | T1D without DN | AA | AG | GG | |||
1657594 | R = A/G | All | 10 (1.61) | 123 (19.84) | 487 (78.55) | 0.115 | |||
Male | 3 (1.20) | 52 (20.71) | 196 (78.09) | 0.116 | |||||
Female | 7 (1.90) | 71 (19.24) | 291 (78.86) | 0.115 | |||||
T1D with DN | |||||||||
All | 3 (0.46) | 130 (19.73) | 526 (79.81) | 0.103 | P = 0.877 | P = 0.576 | |||
Male | 1 (0.29) | 77 (22.12) | 270 (77.59) | 0.114 | P = 0.721 | P = 0.884 | |||
Female | 2 (0.64) | 53 (17.04) | 256 (82.32) | 0.092 | P = 0.413 | P = 0.258 | |||
rs5498 | Exon 6 | E469K | T1D without DN | GG | GA | AA | |||
1658485 | R = A/G | All | 121 (19.58) | 326 (52.75) | 171 (27.67) | 0.460 | |||
Male | 50 (20.08)) | 130 (52.21) | 69 (27.71) | 0.462 | |||||
Female | 71 (19.24) | 196 (53.12) | 102 (27.64) | 0.458 | |||||
T1D with DN | |||||||||
All | 141 (21.30) | 311 (46.98) | 210 (31.72) | 0.448 | P = 0.052 | P = 0.113 | |||
Male | 75 (21.43) | 176 (50.28) | 99 (28.29) | 0.466 | P = 0.766 | P = 0.853 | |||
Female | 66 (21.15) | 135 (43.27) | 111 (35.58) | 0.428 | P = 0.010¤ | P = 0.026# | |||