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Table 2 Genotypic distributions in obese and non-obese subjects by glycemic status

From: The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies

  

Non-obese

Obese

Gene

SNP

Genotype 1-1

Genotype 1-2

Genotype 2-2

Genotype 1-1

Genotype 1-2

Genotype 2-2

  

T2D

NG

T2D

NG

T2D

NG

T2D

NG

T2D

NG

T2D

NG

ADIPOQ

rs17300539

0.82 (1,011)

0.82 (2,579)

0.16 (199)

0.17 (541)

0.01 (16)

0.01 (37)

0.81 (1238)

0.84 (1059)

0.18 (274)

0.15 (189)

0.01 (15)

0.01 (15)

ADIPOQ

rs266729

0.56 (682)

0.56 (1,753)

0.38 (461)

0.37 (1164)

0.07 (83)

0.07 (228)

0.55 (860)

0.6 (761)

0.39 (611)

0.33 (425)

0.06 (89)

0.07 (85)

ENPP1

rs1044498

0.73 (893)

0.72 (2,227)

0.25 (308)

0.25 (785)

0.02 (29)

0.03 (79)

0.7 (1086)

0.74 (917)

0.27 (414)

0.23 (286)

0.03 (53)

0.03 (32)

PPARG

rs1801282

0.82 (1010)

0.79 (2498)

0.17 (209)

0.2 (638)

0.01 (9)

0.01 (30)

0.81 (1232)

0.76 (920)

0.18 (270)

0.22 (270)

0.01 (19)

0.02 (20)

RETN

rs1862513

0.48 (590)

0.49 (1499)

0.43 (533)

0.41 (1249)

0.09 (107)

0.1 (291)

0.5 (775)

0.48 (572)

0.4 (626)

0.44 (530)

0.1 (150)

0.08 (102)

GCK

rs1799884

0.64 (747)

0.68 (2045)

0.32 (369)

0.29 (858)

0.04 (48)

0.03 (97)

0.65 (960)

0.67 (775)

0.32 (466)

0.3 (347)

0.03 (47)

0.03 (37)

HNF1A

rs1169288

0.44 (532)

0.47 (1373)

0.44 (539)

0.43 (1270)

0.12 (151)

0.1 (295)

0.47 (718)

0.44 (537)

0.43 (658)

0.44 (538)

0.11 (168)

0.12 (143)

HNF4A

rs1884614

0.68 (840)

0.69 (2163)

0.29 (354)

0.28 (873)

0.03 (35)

0.03 (87)

0.7 (1078)

0.69 (825)

0.28 (429)

0.28 (340)

0.03 (44)

0.03 (31)

HNF4A

rs2144908

0.68 (814)

0.69 (2153)

0.3 (355)

0.28 (873)

0.03 (34)

0.03 (91)

0.69 (1051)

0.68 (811)

0.28 (429)

0.29 (348)

0.03 (43)

0.03 (31)

KCNJ11

rs5219

0.41 (489)

0.38 (1145)

0.45 (537)

0.48 (1438)

0.15 (180)

0.15 (439)

0.41 (623)

0.4 (480)

0.45 (683)

0.47 (568)

0.15 (222)

0.14 (164)

SLC30A8

rs13266634

0.55 (661)

0.49 (1497)

0.38 (455)

0.42 (1264)

0.08 (94)

0.09 (275)

0.53 (792)

0.51 (617)

0.4 (599)

0.42 (509)

0.08 (114)

0.08 (93)

TCF7L2

rs7903146

0.3 (366)

0.48 (1,512)

0.5 (607)

0.42 (1326)

0.2 (243)

0.09 (290)

0.41 (626)

0.5 (614)

0.46 (715)

0.41 (502)

0.13 (203)

0.1 (119)

  1. Data presented as Frequency (n)
  2. T2D: Type 2 diabetic
  3. NG: Normoglycemic
  4. Non-obese: BMI < 30 kg/m2
  5. Obese: BMI ≥ 30 kg/m2
  6. 1: Major allele
  7. 2: Minor allele
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BMC Medical Genetics

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