Immunological profile in a family with nephrogenic diabetes insipidus with a novel 11 kb deletion in AVPR2 and ARHGAP4 genes

Table 2 Immunological evaluation of NDI patients

	III-3 32 yr	III-4 29 yr	IV-4 5 yr	Normal range (adult)	Normal range (children)
CD3+ [%]	74.3	68.9	85.9	55–78	55–83
CD4+/CD3+ [%]	54.9	17.7	69.6	28–57	27–53
CD8+/CD3+ [%]	34.5	61.8	14	10–39	19–34
CD4/CD8	1.6	0.3	5	1.0–3.6	0.9–2.6
CD19+ [%]	5.2	5.7	6.7	6–19	10–31
IgG (mg/dl)	810.0	741.0	754.0	870–1700	600–1450
IgA (mg/dl)	147.0	72.0	105.0	110–410	39–233
IgM (mg/dl)	59.0	127.0	72.0	33–190	69–268
TREC/μgDNA	1.9 × 10²	2.8 × 10²	1.6 × 10³	3.4 ± 3.6 × 10²	3.5 ± 2.8 × 10³

The normal range of the lymphocyte subpopulation was lower and the upper confidence limit at a confidence level of 0.95. The normal range of IgG, IgA, and IgM are calculated as mean - 2SD (lower) and mean + 2SD (upper). The normal range of TREC is expressed as mean ± SD.

ISSN: 1471-2350