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Table 2 Genotype and allele frequencies of three FTO SNPs in cases/controls and discordant sisters. Significance for case-control and thin-obese sister allele frequency comparisons are given in the right column. Genotype comparisons are presented in Table 3.

From: FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs

  N Genotypes Alleles Allele Freq. Difference
rs1421085   TT TC CC T C  
Controls 521 .370 .518 .111 .630 .370  
Cases 523 .256 .474 .270 .493 .507 p = 3.5 × 10-10
Thin Sisters 92 .337 .554 .109 .614 .386  
Obese Sisters 93 .247 .548 .204 .522 .478 p = 0.07
rs17817449   TT TG GG T G  
Controls 522 .393 .496 .111 .641 .359  
Cases 527 .275 .469 .256 .509 .491 p = 1.2 × 10-9
Thin Sisters 98 .347 .571 .082 .633 .367  
Obese Sisters 93 .258 .516 .226 .516 .484 p = 0.02
rs9939609   TT TA AA T A  
Controls 520 .398 .494 .108 .645 .355  
Cases 527 .288 .459 .252 .518 .482 p = 3.7 × 10-9
Thin Sisters 98 .367 .541 .092 .638 .362  
Obese Sisters 92 .272 .489 .239 .516 .484 p = 0.02