The estrogen hypothesis of Schizophrenia implicates glucose metabolism: Association study in three independent samples

Table 3 Minor allele frequency and associated p-values for markers showing nominal significant allelic effect

					Allelic association adjusted for
			Minor allele frequency		Nationality			Gender
Gene	Marker	Variants¹	Cases	Controls	OR	CI (95%)	P_nat (P_BD)²	P_sex (P_BD)³
MAPK14	rs9470207	C/T	0.01	0.02	0.52	(0.30–0.92)	0.02 (0.25)	0.02 (0.97)
MAPK14	rs6908372	T/A	0.01	0.02	0.54	(0.31–0.96)	0.03 (0.25)	0.03 (0.93)
MAPK14	rs9462156	A/G	0.01	0.02	0.56	(0.32–1.00)	0.04 (0.36)	0.04 (0.91)
PCK1	rs1040566	C/A	0.11	0.09	1.27	(1.02–1.59)	0.04 (0.82)	0.05 (0.23)
FBP1	rs4129219	C/T	0.19	0.17	1.20	(1.01–1.43)	0.04 (0.92)	0.09 (0.45)

OR: odds ratio, CI(95%): 95% confidence interval for the OR
¹ The minor allele is give prior to the major allele
²P-values are for the Cochrane-Mantel-Haenszel tests adjusted for potential presence of stratification between countries. P-values for the Breslow-Day test statistics for odds ratio heterogeneity between countries are given in ()
³P-values are for the Cochrane-Mantel-Haenszel tests adjusted for potential presence of stratification between men and women in all 3 countries. P-values for the Breslow-Day test statistics for OR heterogeneity between gender are given in ()

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