Table 3 Distribution of significant associations between non-APOE polymorphisms and AD. LD = linkage disequilibrium, MDR = multi-dimensionality reduction, LR = logistic regression, AoO = age of onset, ●● = significant at the modified FDR α level, or, in the case of MDR, according to a priori significance criteria: for significant MDR results, the proportion of 10 CVs that identified this model as best and proportion of 10 CVs in which this model produced a training accuracy >0.5 are listed; ● = approaching significance (p <= 0.05, the experimentwise α). Note the consistent identification of lhcgr2/APOE as a significant interaction in males. CV = cross-validation.

From: A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E ε4 allele