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Table 3 Distribution of significant associations between non-APOE polymorphisms and AD. LD = linkage disequilibrium, MDR = multi-dimensionality reduction, LR = logistic regression, AoO = age of onset, = significant at the modified FDR α level, or, in the case of MDR, according to a priori significance criteria: for significant MDR results, the proportion of 10 CVs that identified this model as best and proportion of 10 CVs in which this model produced a training accuracy >0.5 are listed; = approaching significance (p <= 0.05, the experimentwise α). Note the consistent identification of lhcgr2/APOE as a significant interaction in males. CV = cross-validation.

From: A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E ε4 allele

Loci Dataset χ2 AoO LD MDR LR
lhb2     
lhcgr2  
(p = 0.001; α = 0.0077)
   
lhcgr1/lhb1      
lhcgr1/lhb5      
lhcgr2/APOE   
(p = 0.002; α = 0.0077)

(0.8 CVs; 0.7 CVs)

(p = 0.003; α = 0.0077)
lhcgr5/lhb2     
lhcgr5/lhb4     
lhcgr5/lhb5      
lhcgr2/lhcgr5/APOE    
(0.7 CVs; 0.9 CVs)
 
lhcgr2/APOE      
lhb3/APOE   
(p < 0.0001; α = 0.0081)
  
lhb5/APOE    
(0.5 CVs; 1.0 CVs)
 
lhcgr1/lhb1 Total      
lhb3/APOE Total   
(p < 0.0001; α = 0.0082)
  
lhcgr1/lhcgr2/APOE Total    
(0.6 CVs; 0.9 CVs)