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Table 2 Loci exhibiting pairwise linkage disequilibrium at p <= 0.05. Bold-faced loci indicate a combination detected at the α = 0.05 level in an AD stratum but not in the corresponding control stratum. These multi-locus combinations were used as models in LR analyses.

From: A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E ε4 allele

  Loci D' p-value   Loci D' p-value
AD males lhcgr1/lhb1 0.576 0.029 Control males lhcgr1/lhb3 1.000 0.019
  lhcgr1/lhb5 0.388 0.020   lhcgr1/lhb5 0.494 0.033
  lhcgr2/ APOE 1.000 0.002a   lhcgr4/APOE 0.643 0.048
  lhcgr5/lhb2 0.305 0.023   lhcgr5/APOE 0.746 0.047
  lhcgr5/lhb4 0.293 0.033     
  lhcgr5/lhb5 0.335 0.028     
AD females lhcgr2/APOE 0.520 0.032 Control females lhcgr1/lhb1 0.415 0.004b
  lhb3/ APOE 0.718 <0.0001b   lhcgr1/APOE 0.281 0.031
      lhcgr2/APOE 0.315 0.007b
All AD lhcgr1/lhb1 0.465 0.017 All Control lhcgr1/lhb1 0.352 0.006c
  lhb3/ APOE 0.540 <0.0001c   lhcgr1/lhb2 0.419 0.021
      lhcgr2/APOE 0.265 0.044
All males lhcgr1/lhb1 0.387 0.004a All females lhcgr1/lhb1 0.369 0.01a
  lhcgr1/lhb2 0.301 0.047   lhcgr2/APOE 0.294 0.019
  lhcgr1/lhb3 0.365 0.009a   lhb3/APOE 0.296 0.041
  lhcgr1/lhb4 0.312 0.038     
  lhcgr1/lhb5 0.458 0.001a     
  lhcgr1/lhb6 0.323 0.028     
  1. a significant at the corrected α = 0.0077 level (modified FDR) for the male dataset
  2. b significant at the corrected α = 0.0082 level (modified FDR) for the female dataset
  3. c significant at the corrected α = 0.0081 level (modified FDR) for the total dataset.