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Table 2 Loci exhibiting pairwise linkage disequilibrium at p <= 0.05. Bold-faced loci indicate a combination detected at the α = 0.05 level in an AD stratum but not in the corresponding control stratum. These multi-locus combinations were used as models in LR analyses.

From: A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E ε4 allele

 

Loci

D'

p-value

 

Loci

D'

p-value

AD males

lhcgr1/lhb1

0.576

0.029

Control males

lhcgr1/lhb3

1.000

0.019

 

lhcgr1/lhb5

0.388

0.020

 

lhcgr1/lhb5

0.494

0.033

 

lhcgr2/ APOE

1.000

0.002a

 

lhcgr4/APOE

0.643

0.048

 

lhcgr5/lhb2

0.305

0.023

 

lhcgr5/APOE

0.746

0.047

 

lhcgr5/lhb4

0.293

0.033

    
 

lhcgr5/lhb5

0.335

0.028

    

AD females

lhcgr2/APOE

0.520

0.032

Control females

lhcgr1/lhb1

0.415

0.004b

 

lhb3/ APOE

0.718

<0.0001b

 

lhcgr1/APOE

0.281

0.031

     

lhcgr2/APOE

0.315

0.007b

All AD

lhcgr1/lhb1

0.465

0.017

All Control

lhcgr1/lhb1

0.352

0.006c

 

lhb3/ APOE

0.540

<0.0001c

 

lhcgr1/lhb2

0.419

0.021

     

lhcgr2/APOE

0.265

0.044

All males

lhcgr1/lhb1

0.387

0.004a

All females

lhcgr1/lhb1

0.369

0.01a

 

lhcgr1/lhb2

0.301

0.047

 

lhcgr2/APOE

0.294

0.019

 

lhcgr1/lhb3

0.365

0.009a

 

lhb3/APOE

0.296

0.041

 

lhcgr1/lhb4

0.312

0.038

    
 

lhcgr1/lhb5

0.458

0.001a

    
 

lhcgr1/lhb6

0.323

0.028

    
  1. a significant at the corrected α = 0.0077 level (modified FDR) for the male dataset
  2. b significant at the corrected α = 0.0082 level (modified FDR) for the female dataset
  3. c significant at the corrected α = 0.0081 level (modified FDR) for the total dataset.