Table 4 Haplotype Interactions between Blocks, i.e. interactions between polymorphisms in genes that are located on different chromosomes. Significant up- or down- interaction is indicated with bold typeface.
Block Pair/Chrom.Loc.Or SNP Pair/Gene Pair | NGT (control) | IGM | T2DM | |||
|---|---|---|---|---|---|---|
| Â | P Value | Z Score | P Value | Z Score | P Value | Z Score |
(1,5)/(1,5) | 0.025 | -2.11 | 0.440 | -0.17 | 0.145 | -1.00 |
(V2:V15)/(AGT:ADRB2) | 0.005 | -3.80 | 0.055 | -1.73 | <0.001 | -5.62 |
(V4:V15)/(NPPA:ADRB2) | 0.015 | -3.00 | 0.455 | 0.11 | 0.410 | -0.35 |
(V7:V16)/(SELE:ITGA2) | 0.900 | 1.14 | 0.365 | -0.78 | <0.001 | -0.44 |
(1,6)/(1,6) | 0.025 | -1.80 | 0.860 | 2.55 | 0.925 | 1.46 |
(V3:V21)/(NPPA:TNF) | 0.060 | -2.29 | 0.835 | 0.17 | 0.975 | 0.17 |
(2,3)/(2,3) | 0.010 | -2.45 | 0.890 | 1.13 | 0.890 | 1.17 |
(2,10)/(2,12) | 0.030 | -1.91 | 0.585 | 0.29 | 0.200 | -0.66 |
(V8:V49)/(APOB:SCNN1A) | 0.010 | -3.12 | 0.595 | 0.20 | 0.340 | -0.24 |
(V8:V50)/(APOB:GNB3) | 0.195 | -0.71 | 0.245 | -0.82 | 0.005 | -0.73 |
(2,13)/(2,16) | 0.240 | -0.61 | 0.865 | 1.15 | 0.005 | -3.19 |
(V8:V56)/(APOB:CETP) | 0.760 | 0.80 | 0.915 | 1.14 | 0.005 | -0.70 |
(3,5)/(3,5) | 0.660 | 0.38 | 0.825 | 0.97 | <0.001 | -2.72 |
(3,16)/(3,21) | 0.170 | -0.75 | 0.410 | -0.15 | 0.030 | -2.12 |
(5,16)/(5,21) | 0.615 | 0.41 | 0.910 | 1.26 | 0.025 | -2.35 |
(V15:V67)/(ADRB2:CBS) | 0.515 | 0.33 | 0.610 | 0.17 | 0.000 | -4.06 |
(6,10)/(6,12) | <0.001 | -3.70 | 0.755 | 0.71 | 0.915 | 1.26 |
(V18:V50)/(LPA:GNB3) | 0.020 | -3.05 | 0.905 | 0.90 | 0.935 | 0.97 |
(V21:V48)/(TNF:SCNN1A) | 1.000 | 0.75 | 0.035 | -4.20 | 0.086 | 0.09 |
(6,11)/(6,13) | 0.205 | -0.58 | <0.001 | -3.45 | 0.700 | 0.59 |
(V18:V51)/(LPA:F7) | 0.695 | 0.38 | 0.010 | -2.44 | 0.825 | 0.50 |
(V18:V52)/(LPA:F7) | 0.370 | -0.21 | 0.005 | -3.57 | 0.900 | 0.18 |
(6,16)/(6,21) | <0.001 | -5.76 | 0.335 | -0.34 | 0.155 | -1.08 |
(V18:V67)/(LPA:CBS) | <0.001 | -10.38 | 0.670 | -0.20 | 0.740 | -0.07 |
(7,12)/(7,15) | 0.205 | -0.81 | 0.545 | 0.07 | 0.020 | -2.29 |
(V28:V53)/(NOS3:LIPC) | 0.570 | 0.37 | 0.215 | -0.94 | 0.025 | -0.94 |
(V30:V53)/(NOS3:LIPC) | 0.045 | -1.96 | 0.715 | 0.56 | 0.105 | -0.53 |
(8,14)/(8,17) | 0.415 | -0.13 | 0.010 | -2.65 | 0.190 | -0.88 |
(V34:V62)/(LPL:ITGB3) | 1.000 | 0.66 | 0.045 | -0.62 | 0.895 | -0.14 |
(V37:V62)/(LPL:ITGB3) | 0.600 | -0.32 | 0.890 | 0.81 | 0.050 | -0.30 |
(9,11)/(11,13) | 0.515 | 0.04 | 0.160 | -1.10 | 0.030 | -1.99 |
(V39:V51)/(APOA4:F7) | 0.925 | -0.01 | 0.575 | -0.58 | 0.020 | -2.54 |
(V39:V52)/(APOA4:F7) | 0.760 | -0.53 | 0.705 | -0.13 | 0.030 | -2.38 |
(V41:V51)/(APOC3:F7) | 0.050 | -0.66 | 0.460 | -0.32 | 0.285 | -0.59 |
(V43:V51)/(APOC3:F7) | 0.005 | -1.43 | 0.895 | 1.14 | 0.790 | 0.68 |
(V43:V52)/(APOC3:F7) | 0.055 | -0.72 | 0.770 | 0.71 | 0.790 | 0.75 |
(12,13)/(15,16) | 0.005 | -2.54 | 0.620 | 0.07 | 0.815 | 0.96 |
(V53:V56)/(LIPC:CETP) | 0.025 | -2.55 | 0.835 | -0.13 | 0.585 | -0.06 |
(V53:V60)/(LIPC:CETP) | 0.040 | -2.13 | 0.580 | 0.21 | 0.100 | -1.48 |
(13,15)/(16,19) | 0.575 | 0.25 | 0.665 | 0.45 | 0.005 | -2.51 |
(V56:V64)/(CETP:APOE) | 0.865 | 0.85 | 0.270 | -1.07 | 0.020 | -2.90 |
(V54:V65)/(CETP:LDLR) | 0.215 | -0.84 | 0.525 | 0.42 | 0.045 | -1.78 |
(V55:V65)/(CETP:LDLR) | 0.035 | -2.51 | 0.820 | 0.82 | 0.255 | -0.90 |
(V56:V63)/(CETP:APOE) | 0.205 | -0.90 | 0.030 | -2.84 | 0.885 | 0.85 |
(V60 :V65)/(CETP:LDLR) | 0.040 | -2.23 | 0.935 | 1.05 | 0.055 | -1.87 |
(14,16)/(17,21) | 0.600 | 0.27 | 0.030 | -2.20 | 0.600 | 0.44 |
(V62:V67)/(ITGB3:CBS) | 0.185 | -0.59 | 0.005 | -5.61 | 0.695 | -0.28 |