Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians

Table 3 Association of OPRM1 SNPs with response to alcohol, as measured by the Subjective High Assessment Scale-Expectations (SHAS-E) questionnaire. Significant values (p < 0.01) are highlighted in bold.

Marker	Minor	Increaser	Subjective High Assessment Scale-Expectations Item
	Allele	Allele	Buzzed	Clumsy	Dizzy	Drunk	Effects	Energy	Good	Great	High	Nausea	Sleepy	Talk	Terrible	Uncom	Total
rs1799971	G	A	0.26	0.84	0.02	0.23	0.67	0.64	0.98	0.49	0.20	0.32	0.02	0.67	0.71	0.07	0.24
rs553202	A	A	0.03	0.10	0.01	0.001	0.10	0.48	0.32	0.64	0.001	0.01	0.15	0.21	0.008	0.008	0.02
rs524731	A	A	0.03	0.10	0.01	0.001	0.09	0.56	0.26	0.94	0.002	0.06	0.13	0.16	0.01	0.07	0.02
rs3778148	T	T	0.02	0.02	0.01	0.01	0.02	0.92	0.39	0.52	0.000	0.003	0.09	0.001	0.11	0.000	0.003
rs1461773	T	T	0.02	0.03	0.01	0.03	0.03	0.94	0.67	0.60	0.003	0.01	0.07	0.005	0.08	0.009	0.01
rs506247	G	G	0.40	0.95	0.51	0.06	0.91	0.58	0.63	0.55	0.35	0.44	0.47	0.48	0.07	0.83	0.64
rs563649	A	A	0.73	0.77	0.56	0.12	0.70	0.91	0.73	0.39	0.84	0.62	0.58	0.38	0.06	0.57	0.91
rs2075572	G	G	0.12	0.04	0.01	0.003	0.31	0.69	0.76		0.21	0.002	0.05	0.74	0.07	0.17	0.06
rs548646	T	T	0.01	0.01	0.001	0.02	0.02	0.12	0.77	0.91	0.06	0.02	0.04	0.03	0.33	0.02	0.005
rs648007	T	T	0.09	0.02	0.01	0.08	0.10	0.21	0.85	0.95	0.12	0.01	0.23	0.09	0.82	0.05	0.03
rs681243	A	A	0.02	0.01	0.001	0.02	0.03	0.15	0.90	0.91	0.05	0.006	0.06	0.06	0.37	0.02	0.007
rs648893	C	C	0.51	0.34	0.37	0.62	0.45	0.09	0.85	0.82	0.78	0.82	0.60	0.28	0.42	0.50	0.41
rs642489	A	A	0.43	0.25	0.31	0.55	0.40	0.09	0.83	0.80	0.79	0.71	0.45	0.28	0.50	0.55	0.36

The increaser allele for the TOTAL phenotype (i.e., the allele associated with a higher TOTAL score)
TOTAL = sum of scores reported for the first 12 SHAS-E items.

ISSN: 1471-2350