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Table 1 OPRM1 marker information, including genetic map position, location within OPRM1 and minor allele frequency.

From: Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians

Marker Name Gene Chromosomal Functional Alleles MAFd Referencese
dbSNP Celera Location Location (bp)a Location (bp)b Minorc Major Indian CEPH China Japan Yoruba  
rs1799971 hCV8950074 Exon 1 154,402,490 +118 G A 0.13 0.17 0.36 0.49 0.01 1,2,3,4,5,6,7,8,9,10
rs553202 hCV809975 Intron 1 154,406,510 +4,138 A G 0.33 0.20 nd nd 0.41  
rs524731 hCV809963 Intron 1 154,416,785 +14,413 A C 0.32 0.18 0.04 0.02 0.05 1,3,4
rs3778148 hCV27499812 Intron 1 154,422,705 +20,333 T G 0.08 0.14 0.04 0.02 0.04  
rs1461773 hCV8949980 Intron 1 154,433,062 +30,690 T C 0.16 0.14 0.04 0.03 0.08  
rs506247 hCV27335981 Intron 1 154,437,620 +35,248 G T 0.21 0.04 0.00 0.00 0.01  
rs563649 hCV809947 Intron 1 154,449,660 +47,288 A G 0.24 0.08 0.13 0.06 0.16 1
rs2075572 hCV1691815 Intron 2 154,453,697 +51,325 G C 0.39 0.43 0.20 0.21 0.62 1,2,3,4
rs548646 hCV3073603 Intron 3 154,459,840 +57,468 T C 0.18 0.33 0.07 0.13 0.46 1,3
rs648007 hCV1691794 Intron 3 154,464,304 +61,932 T C 0.18 0.33 0.07 0.13 0.46 1
rs681243 hCV3073596 Intron 3 154,469,434 +67,062 A G 0.18 0.24 0.06 0.14 0.43  
rs648893 hCV3073587 Intron 3 154,480,321 +77,949 C T 0.11 0.20 0.05 0.10 0.04 1,3,4,5
rs642489 hCV3073582 3' UTR 154,484,368 +81,996 A C 0.11 0.21 0.04 0.10 0.13  
  1. abp = base-pair position on NCBI Genome Build 127.
  2. bPosition relative to transcription start site at 154,402,372 on Chromosome 6 (NCBI Genome Build 127).
  3. cThe allele with the lowest frequency.
  4. dMAF = Minor Allele Frequency for the Indian tribes studied (Indians) and the reference populations CEPH (European), China, Japan, Yoruba (African). nd = no data.
  5. eReports where each SNP has previously been genotyped: 1. Xuei et al., 2007 [100]; 2. D. Zhang et al., 2007 [98]; 3. H. Zhang et al., 2006 [99]; 4. L. Zhang et al., 2006 [101]; 5. Gelernter et al., 2007 [33]; 6. Luo et al., 2003 [97]; 7. Smith et al., 2005 [102]; 8. Crowley et al., 2003 [103]; 9. Shi et al., 2002 [104]; 10 Y. Zhang et al. 2005 [12].