Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians

Table 1 OPRM1 marker information, including genetic map position, location within OPRM1 and minor allele frequency.

Marker Name		Gene	Chromosomal	Functional	Alleles		MAF^d					References^e
dbSNP	Celera	Location	Location (bp)^a	Location (bp)^b	Minor^c	Major	Indian	CEPH	China	Japan	Yoruba
rs1799971	hCV8950074	Exon 1	154,402,490	+118	G	A	0.13	0.17	0.36	0.49	0.01	1,2,3,4,5,6,7,8,9,10
rs553202	hCV809975	Intron 1	154,406,510	+4,138	A	G	0.33	0.20	nd	nd	0.41
rs524731	hCV809963	Intron 1	154,416,785	+14,413	A	C	0.32	0.18	0.04	0.02	0.05	1,3,4
rs3778148	hCV27499812	Intron 1	154,422,705	+20,333	T	G	0.08	0.14	0.04	0.02	0.04
rs1461773	hCV8949980	Intron 1	154,433,062	+30,690	T	C	0.16	0.14	0.04	0.03	0.08
rs506247	hCV27335981	Intron 1	154,437,620	+35,248	G	T	0.21	0.04	0.00	0.00	0.01
rs563649	hCV809947	Intron 1	154,449,660	+47,288	A	G	0.24	0.08	0.13	0.06	0.16	1
rs2075572	hCV1691815	Intron 2	154,453,697	+51,325	G	C	0.39	0.43	0.20	0.21	0.62	1,2,3,4
rs548646	hCV3073603	Intron 3	154,459,840	+57,468	T	C	0.18	0.33	0.07	0.13	0.46	1,3
rs648007	hCV1691794	Intron 3	154,464,304	+61,932	T	C	0.18	0.33	0.07	0.13	0.46	1
rs681243	hCV3073596	Intron 3	154,469,434	+67,062	A	G	0.18	0.24	0.06	0.14	0.43
rs648893	hCV3073587	Intron 3	154,480,321	+77,949	C	T	0.11	0.20	0.05	0.10	0.04	1,3,4,5
rs642489	hCV3073582	3' UTR	154,484,368	+81,996	A	C	0.11	0.21	0.04	0.10	0.13

^abp = base-pair position on NCBI Genome Build 127.
^bPosition relative to transcription start site at 154,402,372 on Chromosome 6 (NCBI Genome Build 127).
^cThe allele with the lowest frequency.
^dMAF = Minor Allele Frequency for the Indian tribes studied (Indians) and the reference populations CEPH (European), China, Japan, Yoruba (African). nd = no data.
^eReports where each SNP has previously been genotyped: 1. Xuei et al., 2007 [100]; 2. D. Zhang et al., 2007 [98]; 3. H. Zhang et al., 2006 [99]; 4. L. Zhang et al., 2006 [101]; 5. Gelernter et al., 2007 [33]; 6. Luo et al., 2003 [97]; 7. Smith et al., 2005 [102]; 8. Crowley et al., 2003 [103]; 9. Shi et al., 2002 [104]; 10 Y. Zhang et al. 2005 [12].

ISSN: 1471-2350