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Table 1 Results of non-parametric linkage analysis on the whole genome implemented using Merlin software. Position (cM) refers to the genetic position of the maximum LOD score, while Position (bp) refers to the physical position given in build 36.1 of the genome (NCBI)

From: Genetic loci linked to Type 1 Diabetes and Multiple Sclerosis families in Sardinia

Scan

Chromosome

Position(cM)

Position(bp)

Closest Marker

LOD

P Value

λs

CI

% Information_Content

T1D_SCAN

1p31.1

109.48

82315937

D1S207

1.7

3.0 × 10-3

1.35

0.91 – 1.99

79

 

6p21.32 (HLA)

40.48

32734820

D6S2447

8.3

< 1.0 × 10-5

2.81

1.56 – 5.07

71

 

6q26

160.77

162759585

D6S1599

1.1

1.1 × 10-2

1.46

0.97 – 2.19

77

 

10q21.2

78.64

64077501

D10S1652

1.1

1.3 × 10-2

1.33

0.89 – 2.00

70

 

22q11.22

10.38

20587780

D22S539

1.5

4.0 × 10-3

1.89

1.05 – 2.57

66

MS_SCAN

1q42.2

246.27

232524978

D1S2800

1

2.0 × 10-2

2.23

1.06 – 4.70

61

 

18p11.21

41.24

11482730

D18S53

1.6

3.0 × 10-3

3.2

1.28 – 7.99

64

 

20p12.3

18.32

7607867

D20S115

1.1

1.3 × 10-2

1.8

0.93 – 3.47

76

T1D-MS_SCAN

6p21.32 (HLA)

39.65

32734723

D6S2447

5.1

< 1.0 × 10-5

1.65

1.15 – 2.34

69

 

6q26

157.21

162115167

D6S305

1.2

9.0 × 10-3

1.25

0.93 – 1.69

79

 

10q21.2

82.093

64077501

D10S1652

1.4

6.0 × 10-3

1.33

0.96 – 1.84

63

 

20p12.3

18.32

7607867

D20S115

1.2

1.0 × 10-2

1.39

1.00 – 1.93

71

 

22q11.22

10.38

20587780

D22S539

1.3

8.0 × 10-3

1.51

1.07 – 2.13

65