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Table 4 Genotype counts and ORs for LOX 1.3 in the ADVANCE study combining both sets of cases and controls

From: Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD

    

Recessive

Additive

Dominant

 

Genotype

Cases N (%)

Controls N (%))

minimal model

fully adjusted model

minimal model

fully adjusted model

minimal model

fully adjusted model

LOX1.3

   

OR

CI

OR

CI

OR

CI

OR

CI

OR

CI

OR

CI

White

GG

290 (24)

269 (26)

      
 

GC

603 (51)

560 (54)

1.29*

1.1–1.6

1.3*

1.1–1.6

1.13

1.0–1.3

1.13

1.0–1.3

1.08

0.88–1.3

1.08

0.88–1.3

 

CC

301 (25)

216 (20)

      

Black/AA

GG

55 (58)

223 (67)

      
 

GC

30 (31)

90 (27)

2.31

0.92–5.6

2.5

0.95–6.3

1.47

0.99–2.2

1.49

0.99–2.2

1.49

0.89–2.5

1.49

0.88–2.5

 

CC

10 (11)

18 (6)

      

Hispanic

GG

43 (30)

20 (24)

      
 

GC

45 (45)

41 (50)

1.02

0.5–2.1

0.76

0.34–1.7

0.92

0.6–1.4

0.85

0.53–1.4

0.78

0.38–1.6

0.85

0.39–1.8

 

CC

19 (25)

21 (26)

      

E. Asian

GG

65 (56)

64 (62)

      
 

GC

44 (38)

35 (34)

2.26

0.6–10

2.56

0.64–12

1.26

0.78–2.0

1.25

0.76–2.1

1.2

0.67–2.2

1.16

0.04–2.1

 

CC

7 (6)

4 (4)

      

Mix. Hisp.

GG

21 (25)

11 (21)

      
 

GC

39 (46)

31 (58)

1.39

0.6–3.7

1.45,

0.59–3.7

1.02,

0.59–1.7

1.04

0.6–1.8

0.73

0.29–1.8

0.76

0.3–1.9

 

CC

24 (29)

11 (21)

      

Mix. other

GG

87 (43)

49 (44)

      
 

GC

79 (39)

48 (43)

1.01

0.5–2.1

0.98

0.47–2.1

0.42

0.64–1.4

0.93

0.63–1.4

0.85

0.49–1.5

0.86

0.5–1.5

 

CC

35 (18)

14 (13)

      

All

GG

570 (32)

636 (37)

      
 

GC

847 (47)

805 (47)

1.3*

1.1–1.6

1.32**

1.1–1.6

1.12*

1.0–1.2

1.13*

1.0–1.25

1.06

0.9–1.25

1.07

0.9–1.25

 

CC

380 (21)

284 (16)

      
  1. OR = Odds ratio, ref = reference group, NA = unable to compute, All P values < 0.05 in bold, * P < 0.05, ** P < 0.01
  2. † combined analyses adjusted for race/ethnic group and case/control set
  3. Minimal model adjusted for age, sex. Fully adjusted analyses adjusted for age, sex, BMI, smoking status, hypertension, diabetes, high cholesterol, "admixed" strata further adjusted for proportion of white, black, Hispanic, E. Asian ancestry derived from STRUCTURE analyses. Non-stratified analyses further adjusted by race/ethnic group and cases/control status