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Table 3 Genotype counts and ORs for LOX 1.2 in the ADVANCE study combining both sets of cases and controls

From: Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD

     Recessive Additive Dominant
  Genotype Cases N (%) Controls N (%)) minimal model fully adjusted model minimal model fully adjusted model minimal model fully adjusted model
LOX1.2     OR
CI
OR
CI
OR
CI
OR
CI
OR
CI
OR
CI
White GG 1034 (86) 842 (80)       
  GC 154 (13) 194 (19) 1.44
0.6–3.6
1.59,
0.6–4.0
0.75**
0.6–0.9
0.76*
0.6–0.95
0.69**
0.6–0.9
0.7**
0.6–0.9
  CC 12 (1) 9 (1)       
Black/AA GG 65 (68) 201 (61)       
  GC 30 (31) 118 (36) 0.25
0.01–1.4
0.23
0.01–1.3
0.8
0.5–1.3
0.77
0.47–1.2
0.85
0.5–1.4
0.82
0.5–1.4
  CC 1 (1) 12 (3)       
Hispanic GG 96 (89) 73 (89)       
  GC 12 (11) 9 (11) 1
NA
1
NA
1.05
0.4–2.9
1.18
0.4–3.4
1.05
0.4–2.9
1.18
0.4–3.4
  CC 0 (0) 0 (0)       
E. Asian GG 90 (77) 66 (64)       
  GC 23 (20) 33 (32) 1.02
0.2–4.9
1.94
0.2–4.8
0.61
0.4–1.0
0.56*
0.3–0.98
0.49*
0.3–0.9
0.45*
0.2–0.97
  CC 4 (3) 4 (4)       
Mix. Hisp. GG 72 (86) 48 (89)       
  GC 11 (13) 6 (11) 3E+09
NA
8E+08
NA
1.66
0.6–5.5
1.51
0.5–5.3
1.64
0.5–5.6
1.51
0.46–5.3
  CC 1 (1) 0 (0)       
Mix. other GG 150 (74) 92 (79)       
  GC 53 (26) 21 (18) 0*
NA
0*
NA
1.32
0.8–2.3
1.28
0.73–2.3
1.6
0.9–3.0
1.56
0.8–3.0
  CC 0 (0) 3 (3)       
All GG 1507 (83) 1322 (76)       
  GC 283 (16) 381 (22) 0.8
0.41–1.5
0.8
0.41–1.5
0.8**
0.7–0.9
0.8*
0.7–0.95
0.77**
0.6–0.93
0.78**
0.7–0.94
  CC 18 (1) 28 (2)       
  1. OR = Odds ratio, ref = reference group, NA = unable to compute, All P values < 0.05 in bold, * P < 0.05, ** P < 0.01.
  2. combined analyses adjusted for race/ethnic group and case/control set
  3. Minimal model adjusted for age, sex. Fully adjusted analyses adjusted for age, sex, BMI, smoking status, hypertension, diabetes, high cholesterol, "admixed" strata further adjusted for proportion of white, black, Hispanic, E. Asian ancestry derived from STRUCTURE analyses. Non-stratified analyses further adjusted by race/ethnic group and cases/control status.