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Table 1 Non-genetic characteristics of the ADVANCE study according to case/control status (symptomatic CAD) stratified by two primary predefined comparisons

From: Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD

  Young Cases (n = 472) Young Controls (n = 742) P Older Cases (n = 1337) Older Controls (n = 992) P
  Mean(SD) Mean(SD) T test Mean(SD) Mean(SD) T test
Age(years) * 45.3(6.5) 44.3(5.5) 0.005 62(8.4) 65.8(2.9) <0.001
  Median (Range) Median (Range) Wilcoxon Median (Range) Median (Range) Wilcoxon
Body Mass Index 31.1 (17.3–61.2) 26.8 (15.8–66.2) <0.001 28.4 (16.9–66.1) 27.5 (17.3–52.9) <0.001
C-Reactive Protein 2.3 (0.1–76.4) 1.2 (0.1–76.8) <0.001 1.7 (0.1–77.4) 1.6 (0.1–73.9) 0.163
Months from first ever event to study visit 21.3 (2.7–222.1)† -- -- 3.5 (1.4–26.4)† -- --
  Count(%) Count(%) Chi 2 Count(%) Count(%) Chi 2
Risk Factors (Self Report)       
   Male 184(39) 328(44.2) 0.072 975(72.9) 618(62.3) <0.001
   Current/Former smoker 276(58.5) 266(35.8) <0.001 842(63) 569(57.4) 0.006
   Hypertension 154(32.6) 143(19.3) <0.001 641(47.9) 407(41) <0.001
   Diabetes Mellitus 101(21.4) 51(6.9) <0.001 274(20.5) 147(14.8) <0.001
   High Cholesterol 129(27.3) 148(19.9) 0.003 604(45.2) 356(35.9) <0.001
Ancestry    <0.001    <0.001
   White/European 254(53.8) 369(49.7)   947(70.8) 677(68.2)  
   Black/African American 46(9.7) 254(34.2)   50(3.7) 79(8)  
   Hispanic 25(5.3) 22(3)   83(6.2) 60(6)  
   East Asian 44(9.3) 35(4.7)   73(5.5) 68(6.9)  
Admixed Hispanic 32(6.8) 23(3.1)   52(3.9) 31(3.1)  
Admixed Non-Hispanics 71(15) 39(5.3)   132(9.9) 77(7.8)  
  1. Age was defined at first ever event for cases, study visit date for controls. The age cutoff for a "young case" was not the same for males (<45 years) and females (<55 years). †P < 0.001 for Wilcoxon test.