Table 1 Non-genetic characteristics of the ADVANCE study according to case/control status (symptomatic CAD) stratified by two primary predefined comparisons
From: Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD
| Â | Young Cases (n = 472) | Young Controls (n = 742) | P | Older Cases (n = 1337) | Older Controls (n = 992) | P |
|---|---|---|---|---|---|---|
| Â | Mean(SD) | Mean(SD) | T test | Mean(SD) | Mean(SD) | T test |
Age(years) * | 45.3(6.5) | 44.3(5.5) | 0.005 | 62(8.4) | 65.8(2.9) | <0.001 |
| Â | Median (Range) | Median (Range) | Wilcoxon | Median (Range) | Median (Range) | Wilcoxon |
Body Mass Index | 31.1 (17.3–61.2) | 26.8 (15.8–66.2) | <0.001 | 28.4 (16.9–66.1) | 27.5 (17.3–52.9) | <0.001 |
C-Reactive Protein | 2.3 (0.1–76.4) | 1.2 (0.1–76.8) | <0.001 | 1.7 (0.1–77.4) | 1.6 (0.1–73.9) | 0.163 |
Months from first ever event to study visit | 21.3 (2.7–222.1)†| -- | -- | 3.5 (1.4–26.4)†| -- | -- |
| Â | Count(%) | Count(%) | Chi 2 | Count(%) | Count(%) | Chi 2 |
Risk Factors (Self Report) | Â | Â | Â | Â | Â | Â |
   Male | 184(39) | 328(44.2) | 0.072 | 975(72.9) | 618(62.3) | <0.001 |
   Current/Former smoker | 276(58.5) | 266(35.8) | <0.001 | 842(63) | 569(57.4) | 0.006 |
   Hypertension | 154(32.6) | 143(19.3) | <0.001 | 641(47.9) | 407(41) | <0.001 |
   Diabetes Mellitus | 101(21.4) | 51(6.9) | <0.001 | 274(20.5) | 147(14.8) | <0.001 |
   High Cholesterol | 129(27.3) | 148(19.9) | 0.003 | 604(45.2) | 356(35.9) | <0.001 |
Ancestry | Â | Â | <0.001 | Â | Â | <0.001 |
   White/European | 254(53.8) | 369(49.7) |  | 947(70.8) | 677(68.2) |  |
   Black/African American | 46(9.7) | 254(34.2) |  | 50(3.7) | 79(8) |  |
   Hispanic | 25(5.3) | 22(3) |  | 83(6.2) | 60(6) |  |
   East Asian | 44(9.3) | 35(4.7) |  | 73(5.5) | 68(6.9) |  |
Admixed Hispanic | 32(6.8) | 23(3.1) | Â | 52(3.9) | 31(3.1) | Â |
Admixed Non-Hispanics | 71(15) | 39(5.3) | Â | 132(9.9) | 77(7.8) | Â |