Lack of association of genetic variation in chromosome region 15q14-22.1 with type 2 diabetes in a Japanese population

Table 1 Summary of linkage scan on chromosome 15q14-22.1

Population	Sample	Score	Phenotype	STS marker	Position (cM)	References (year)
Japanese	224 ASP in 159 families, 359 individuals	1.57 MLS	T2D	D15S994	40.25	Mori Y et al. 2002 [11]
		3.91 MLS	T2D (Young-onset < 45)	D15S994	40.25
		2.44 MLS	T2D (BMI < 30)	D15S994	40.25
		1.50 MLS	T2D	D15S118	32.58
		0.95 MLS	T2D	D15S117	51.21
Japanese	256 ASP in 164 families, 368 individuals	2.41 LOD	T2D (BMI < 22)	CYP19	45.62	Iwasaki N et al. 2003 [12]
Japanese	102 ASP in 102 families	0.25 LOD	T2D	D15S117	51.21	Nawata H et al. 2004 [13]
Mexican Americans	330 ASP in 170 families, 408 individuals	1.50 MLS	T2D	D15S119	45.62	Hanis CL et al. 1996 [14]
Pima Indians	388 ASP in 109 families, 363 individuals	1.46 LOD	insulin secretion (IVGTT 10)	D15S659	43.47	Pratley RE et al. 1998 [15]
Mexican Americans	330 ASP in 170 families and 363 nondiabetic individuals	1.27 LOD	T2D	D15S119	45.62	Cox NJ et al. 1999 [16]
	interaction with D15S119 and CYP19	4.00 LOD	T2D	D15S119+ CYP19

ASP, affected sib-pairs; MLS, maximum lod score; LOD, logarithm of odds; IVGTT 10, plasma insulin response at 10 min above the basal level during the intravenous glucose tolerance test; D15S119 + CYP19, D15S119 interaction with CYP19 (NIDDM1). Each report identified nominal evidence of linkage or significant evidence of linkage with LOD > 3.91. Location is shown only for loci with positive evidence of linkage on chromosome 15q. The position is based on the Marshfield recombination genetic map .
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