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Table 1 Summary of linkage scan on chromosome 15q14-22.1

From: Lack of association of genetic variation in chromosome region 15q14-22.1 with type 2 diabetes in a Japanese population

Population Sample Score Phenotype STS marker Position (cM) References (year)
Japanese 224 ASP in 159 families, 359 individuals 1.57 MLS T2D D15S994 40.25 Mori Y et al. 2002 [11]
   3.91 MLS T2D (Young-onset < 45) D15S994 40.25  
   2.44 MLS T2D (BMI < 30) D15S994 40.25  
   1.50 MLS T2D D15S118 32.58  
   0.95 MLS T2D D15S117 51.21  
Japanese 256 ASP in 164 families, 368 individuals 2.41 LOD T2D (BMI < 22) CYP19 45.62 Iwasaki N et al. 2003 [12]
Japanese 102 ASP in 102 families 0.25 LOD T2D D15S117 51.21 Nawata H et al. 2004 [13]
Mexican Americans 330 ASP in 170 families, 408 individuals 1.50 MLS T2D D15S119 45.62 Hanis CL et al. 1996 [14]
Pima Indians 388 ASP in 109 families, 363 individuals 1.46 LOD insulin secretion (IVGTT 10) D15S659 43.47 Pratley RE et al. 1998 [15]
Mexican Americans 330 ASP in 170 families and 363 nondiabetic individuals 1.27 LOD T2D D15S119 45.62 Cox NJ et al. 1999 [16]
  interaction with D15S119 and CYP19 4.00 LOD T2D D15S119+ CYP19   
  1. ASP, affected sib-pairs; MLS, maximum lod score; LOD, logarithm of odds; IVGTT 10, plasma insulin response at 10 min above the basal level during the intravenous glucose tolerance test; D15S119 + CYP19, D15S119 interaction with CYP19 (NIDDM1). Each report identified nominal evidence of linkage or significant evidence of linkage with LOD > 3.91. Location is shown only for loci with positive evidence of linkage on chromosome 15q. The position is based on the Marshfield recombination genetic map .
  2. http://research.marshfieldclinic.org/genetics/Home/index.asp