Figure 2

Association tests on chromosome 15q14-22.1. Allelic p values in association tests are shown. The top window shows reports of linkage with T2D or its related traits on chromosome 15q14-22.1 in the Japanese and other ethnic populations. The solid and open circles denote LOD scores and location in recombination distance. The width of the straight lines or a broken line denote a 1-LOD drop interval when available. The vertical bars show the positions of RefSeq genes (upper) and the 1,317 chosen SNPs (lower) with black vertical bars placed in gene-centric regions and gray vertical bars in intergenic regions. Allelic p values in Stage 1 (372 cases and 360 controls) for 1,317 SNPs (A), in Stage 2 (532 cases and 530 controls) for 112 SNPs (B), and in Stage 1 + Stage 2 combined samples (904 cases and 890 controls) for one replicated SNP (C) were plotted against physical positions. The data denote the -log p, and p = 0.05 is shown with a thick line. The landmark SNP2140 (rs2412747) is indicated with an arrow.