Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission

Table 4 Genotyping of the TGFβ1 -508 T>C SNP (rs1800469) in 423 informative MS trio families.

The samples were stratified and both corrected and uncorrected p-values were calculated to avoid type I and type II errors. There is a trend for over-transmission of the T allele in MS (p < 0.13), and an association in females (p_uncorrected<0.04), HLA-DR+ (p_uncorrected<0.01), which was also found when data was combined from a second independent cohort (SMSGC), but was not significant after correction for multiple testing. However, the IMSGC transmission was in the reverse order, with C overtransmitted [10]. This was inferred from the transmission of rs2241714, which is in LD with rs1800469.

ISSN: 1471-2350