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Table 2 Dysregulated genes from patients in relapse and remission encoded in genomic regions associated with MS.

From: Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission

Chromosomal Region Associated with MS Genes Upregulated in Relapse Genes Downregulated in Relapse
5q331 SOX30 0
17q231 FTSJ3, USP32, MRC2, TLK2, PRKAR1A SMARCD2, HAN11WD
19p131 CD97, HOMER3, THRAP5, ILF3, OAZ1, AES, FUTC, SAFB, C19ORF6, ARHGEF18, SF4, GADD45B, CYP4F12 RGS19IP1, DHPS, MGC11271, KLF1, GCDH, FLJ90396, AZU1, FARSLA, KHSRP, TRIP10, ILVB1, ANGPTL4, NDUB7, NDUFA, MADCAM17
11q23 (D11S1986) 2 0 0
19q13.2 (D19S552) 2 TGFB1, CEACAM1, GMF 0
20p12 (D20S894) 2 0 0
IMSGC3 TAF1A FHIT, DBC1
  Genes Upregulated in Remission Genes Downregulated in Remission
5q331 0 0
17q231 0 0
19p131 0 0
11q23 (D11S1986) 2 SDHD, CASP1, SIAT4C, APLP2 MGC2574, CD3E, RARRES3, CD3G, MTVR1, PCSK7
19q13.2 (D19S552) 2 CEACAM4, VASP PSG6, HNRPUL1, PVR, EIF3S12
20p12 (D20S894) 2 0 0
IMSGC3 CD58 FHIT
  1. Chromosomal regions are those identified as associated by Sawcer et al (2005)1 [27] from the family study or by the GAMES collaboration (2006)2 [26] using microsatellites (as marked) in a case/control study, and from the IMSGC SNP based genome wide analysis3 [10]. Genes are from the set of genes dysregulated in relapse and remission. Highlighted genes have been associated with MS in replication cohorts.