Table 1 GO pathways over-represented in the relapse and remission upregulated gene sets.

GO:0009607 – Response to biotic stimulus

GPR65, NMI, TAP2, IFI16, CSF2RB, TCRIM, ICOS, FCGR2B, CD48, BST1, TNFSF10, TLR5, MCP, DNAJB6, MNDA, GBP2, OXSR1, AQP9, TNFAIP6, NFIL3, CD53, GEM, LY96, DOCK2, IL1B, CLECSF6, PARP4, PLA2G7, CD97, MX2, 5233, HSPA1B, MAPK14, IL1R2, C3AR1, IFIT2, STAT1, IFNGR1, S100A8, EDEM1, LYZ, FAS, HSPA1L, LTBR, IL1RL1, B2M, HSPA1A

GO:0008219 – Cell death

PARP4, GADD45B, MCL1, BCL2, GPR65, SMNDC1, RAF1, BIRC2, RAD21, CASP3, CASP10, TXNL1, BCLAF1, API5, STAT1, CUL1, YWHAG, TNFSF10, GADD45G, LYZ, FAS, IL1B, TRAF5, LTBR, TAX1BP1, CASP1, BID

GO:0006955 – Immune response

GPR65, NMI, TAP2, IFI16, CSF2RB, TCRIM, ICOS, FCGR2B, BST1, TNFSF10, TLR5, MCP, MNDA, GBP2, AQP9, NFIL3, TNFAIP6, CD53, GEM, DOCK2, LY96, IL1B, CLECSF6, PARP4, PLA2G7, CD97, MX2, MAPK14, IL1R2, C3AR1, IFIT2, S100A8, FAS, LTBR, IL1RL1, B2M

GO:0016265 – Death

PARP4, GADD45B, MCL1, BCL2, GPR65, SMNDC1, RAF1, BIRC2, RAD21, CASP3, CASP10, TXNL1, BCLAF1, API5, STAT1, CUL1, YWHAG, TNFSF10, GADD45G, LYZ, FAS, IL1B, TRAF5, LTBR, TAX1BP1, CASP1, BID

GO:0006952 – Defense response

GPR65, NMI, TAP2, IFI16, CSF2RB, TCRIM, ICOS, FCGR2B, CD48, BST1, TNFSF10, TLR5, MCP, MNDA, GBP2, AQP9, NFIL3, TNFAIP6, CD53, GEM, DOCK2, LY96, IL1B, CLECSF6, PARP4, PLA2G7, CD97, MX2, MAPK14, IL1R2, C3AR1, IFIT2, S100A8, LYZ, FAS, LTBR, IL1RL1, B2M

GO:0004722 – Protein serine/threonine phosphatase activity

MTMR6, PPM1A, PPM1B, DUSP6, PPP2R2A, MTMR1

GO:0006915 – Apoptosis

GADD45B, MCL1, BCL2, GPR65, SMNDC1, RAF1, BIRC2, RAD21, CASP3, CASP10, TXNL1, BCLAF1, API5, STAT1, YWHAG, CUL1, TNFSF10, GADD45G, FAS, IL1B, TRAF5, LTBR, TAX1BP1, CASP1, BID

GO:0012501 – Programmed cell death

GADD45B, MCL1, BCL2, GPR65, SMNDC1, RAF1, BIRC2, RAD21, CASP3, CASP10, TXNL1, BCLAF1, API5, STAT1, YWHAG, CUL1, TNFSF10, GADD45G, FAS, IL1B, TRAF5, LTBR, TAX1BP1, CASP1, BID

GO:0005057 – Receptor signaling protein activity

STAT1, TGFBR2, RAF1, LYN, ACVR1B, MAPK14, NSMAF, MAPK9, IRS1, TCRIM, IL1RL1, PDLIM5, MAPK8

GO:0015031- protein transport

STXBP3, RANBP6, RAB2, PTTG1IP, ARF1, STX7, SNX2, GRP58, TLOC1, KPNB1, VDP, SNAG1, CLTC, COPB, TMED7, ARF3, RAB5A, TNPO1, RAB1A, COPA, RAB7, TLK1

GO:0045184 – establishment of protein localization

STXBP3, RANBP6, RAB2, PTTG1IP, ARF1, STX7, SNX2, GRP58, TLOC1, KPNB1, VDP, SNAG1, CLTC, COPB, TMED7, ARF3, RAB5A, TNPO1, RAB1A, COPA, RAB7, TLK1

GO:0008104 – protein localization

STXBP3, RANBP6, RAB2, PTTG1IP, ARF1, STX7, SNX2, GRP58, TLOC1, KPNB1, VDP, SNAG1, CLTC, COPB, TMED7, ARF3, RAB5A, TNPO1, RAB1A, COPA, RAB7, TLK1

GO:0005885 – Arp2/3 protein complex

ARPC2, ACTR3, ARPC3

GO:0030833 – regulation of actin filament polymerization

ARPC5, ARPC2, ARPC3