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Table 1 Selected candidate SNPs

From: No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins

SNP

Chromosome

Gene

Alleles*

Risk Allele

Phenotype

TEDS Allele Frequencies

rs1801282

3 p25.2

PPARG

C/G (Pro → Ala)

G

Body Mass Index [33]

C = .88; G = .12

rs5082

1 q23.3

APOA2

C/T (5' near gene)

T

Waist circumference [34]

C = .39; T = .61

rs1042714

5 q32

ADRB2

C/G (Gln → Glu)

C

Body Mass Index [35]

C = .56; G = .44

rs1800206

22 q13.31

PPARA

C/G (Val → Leu)

G

Body Mass Index [36]

C = .93; G = .07

rs6659176

1 p36.11

NROB2

C/G (Ala → Gly)

C

Body Mass Index and waist circumference [37]

C = .92; G = .08

rs5443

12 p13.31

GNB3

C/T (Ser → Ser)

T

Body Mass Index [38]

C = .71; T = .29

rs7754561

6 q23.2

ENPP1

A/G (3' near gene)

G

Body Mass Index [39]

A = .77; G = .23

rs1042713

5 q32

ADRB2

A/G (Arg → Gly)

A

Body Mass Index [35]

A = .36; G = .64

rs4994

8 p12

ADRB3

C/T (Arg → Trp)

C

Body Mass Index [40]

C = .08; T = .92

rs7566605 †

2 q14.1

INSIG2

C/G (intronic)

C

Body Mass Index [21]

C = .33; G = .67

  1. Candidate SNPs were selected based on "The human obesity gene map: the 2005 update" [8]. Nine SNPs were selected based on the following criteria: (1) Association must have been shown in a sample with at least 500 participants. (2) Measured phenotype had to be BMI/obesity or waist circumference. (3) SNP had to have a minor allele frequency greater than 0.1. Genotyping of these nine SNPs was performed by Kbiosciences, UK http://www.kbioscience.co.uk using the competitive allele specific PCR (KASPar) method, on a sample of 5000 children.
  2. * Information about the SNP function class is presented in parentheses; in the case of non-synonymous SNPs the amino acid alteration is given.
  3. † SNP rs7566605 was genotyped in an attempt to replicate a recent report of an association [21]; genotyping for rs7566605 was performed in-house using Taqman on a subsample of 3000 children.
  4. Full gene names:
  5. PPARG/PPARA: Peroxisome Proliferator-Activated Receptors (PPARs).
  6. APOA2: Apolipoprotein A-II.
  7. ADRB2/ADRB3: Beta-2-Adrenergic Receptor/Beta-3-Adrenergic Receptor.
  8. NROB2: Nuclear receptor subfamily 0, group B, member 2.
  9. GNB3: Guanine nucleotide-binding protein, Beta-3.
  10. ENPP1: Ectonucleotide pyrophosphatase/phosphodiesterase 1.
  11. INSIG2: Insulin induced gene 2.
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BMC Medical Genetics

ISSN: 1471-2350

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