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Table 1 Selected candidate SNPs

From: No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins

SNP Chromosome Gene Alleles* Risk Allele Phenotype TEDS Allele Frequencies
rs1801282 3 p25.2 PPARG C/G (Pro → Ala) G Body Mass Index [33] C = .88; G = .12
rs5082 1 q23.3 APOA2 C/T (5' near gene) T Waist circumference [34] C = .39; T = .61
rs1042714 5 q32 ADRB2 C/G (Gln → Glu) C Body Mass Index [35] C = .56; G = .44
rs1800206 22 q13.31 PPARA C/G (Val → Leu) G Body Mass Index [36] C = .93; G = .07
rs6659176 1 p36.11 NROB2 C/G (Ala → Gly) C Body Mass Index and waist circumference [37] C = .92; G = .08
rs5443 12 p13.31 GNB3 C/T (Ser → Ser) T Body Mass Index [38] C = .71; T = .29
rs7754561 6 q23.2 ENPP1 A/G (3' near gene) G Body Mass Index [39] A = .77; G = .23
rs1042713 5 q32 ADRB2 A/G (Arg → Gly) A Body Mass Index [35] A = .36; G = .64
rs4994 8 p12 ADRB3 C/T (Arg → Trp) C Body Mass Index [40] C = .08; T = .92
rs7566605 † 2 q14.1 INSIG2 C/G (intronic) C Body Mass Index [21] C = .33; G = .67
  1. Candidate SNPs were selected based on "The human obesity gene map: the 2005 update" [8]. Nine SNPs were selected based on the following criteria: (1) Association must have been shown in a sample with at least 500 participants. (2) Measured phenotype had to be BMI/obesity or waist circumference. (3) SNP had to have a minor allele frequency greater than 0.1. Genotyping of these nine SNPs was performed by Kbiosciences, UK http://www.kbioscience.co.uk using the competitive allele specific PCR (KASPar) method, on a sample of 5000 children.
  2. * Information about the SNP function class is presented in parentheses; in the case of non-synonymous SNPs the amino acid alteration is given.
  3. † SNP rs7566605 was genotyped in an attempt to replicate a recent report of an association [21]; genotyping for rs7566605 was performed in-house using Taqman on a subsample of 3000 children.
  4. Full gene names:
  5. PPARG/PPARA: Peroxisome Proliferator-Activated Receptors (PPARs).
  6. APOA2: Apolipoprotein A-II.
  7. ADRB2/ADRB3: Beta-2-Adrenergic Receptor/Beta-3-Adrenergic Receptor.
  8. NROB2: Nuclear receptor subfamily 0, group B, member 2.
  9. GNB3: Guanine nucleotide-binding protein, Beta-3.
  10. ENPP1: Ectonucleotide pyrophosphatase/phosphodiesterase 1.
  11. INSIG2: Insulin induced gene 2.