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Table 3 Associations with INSIG2 rs7566605 phenotypes with baseline and percent (%) fat and strength change in FAMUSS cohort with resistance training.

From: INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men

Phenotype Gender P-value N; mean ± SEM 95% CI % variability attributable to genotype; LRT p-value
Baseline subcutaneous fat volume (mm3) Female 0.0011 GG (N = 139; 243473 ± 5713) GC/CC (N = 181; 268521 ± 5003) GG (232233 – 254714) GC/CC (258677 – 278365) 1.1%; 0.0010
Baseline subcutaneous fat volume (mm3) Male 0.3557 GG (N = 103; 176503 ± 6100) GC/CC (N = 94; 168275 ± 6389) GG (164472 – 188534) GC/CC (155675 – 180876) 0.2%; 0.3501
% change in subcutaneous fat volume Female 0.2683 GG (N = 139; 11.20 ± 5.71) GC/CC (N = 181; 2.78 ± 4.99) GG (-0.02 – 22.43) GC/CC (-7.05 – 12.61) 0.4%; 0.2649
% change in subcutaneous fat volume Male 0.0353 GG (N = 103; 1.00 ± 1.74) GC/CC (N = 94; 6.39 ± 1.82) GG (-2.43 – 4.43) GC/CC (2.78 – 10.01) 2.3%; 0.0332
  1. All genetic models were dominant.