Selecting a BRCA risk assessment model for use in a familial cancer clinic

BMC Medical Genetics

Table 5 Sensitivity and specificity at the conventional thresholds

Model	Conventional threshold	Sensitivity at conventional threshold			Specificity at conventional threshold
		All	Low risk subset	High risk subset	All	Low risk subset	High risk subset
*BRCA status*
*BRCAPRO*	10	0.75	0.63	0.82	0.62	0.70	0.58
*Manchester*	15	0.58	0.39	0.64	0.71	0.73	0.72
*Penn II*	10	0.93	0.94	0.92	0.31	0.14	0.40
*Myriad II*	10	0.71	0.66	0.74	0.63	0.65	0.62
*FHAT*	10	0.70	0.34	0.89	0.63	0.85	0.51
*IBIS*	10	0.20	-	-	0.74	-	-
*BOADICEA*	10	0.70	0.63	0.74	0.65	0.70	0.62

ISSN: 1471-2350