Table 4 Area under the receiver operating characteristic (ROC) curve with 95% confidence limits
From: Selecting a BRCA risk assessment model for use in a familial cancer clinic
Model | Area under the ROC curve (95% confidence limits) | ||
|---|---|---|---|
| Â | All | Low risk subset | High risk subset |
BRCA status | Â | Â | Â |
BRCAPRO | 0.76 (0.70 – 0.82) | 0.70 (0.57 – 0.81) | 0.80 (0.73 – 0.87) |
Manchester | 0.68 (0.60 – 0.76) | 0.57 (0.37 – 0.72) | 0.73 (0.63 – 0.81) |
Penn II | 0.74 (0.67 – 0.80) | 0.68 (0.54 – 0.79) | 0.77 (0.70 – 0.83) |
Myriad II | 0.76 (0.71 – 0.82) | 0.70 (0.59 – 0.80) | 0.80 (0.72 – 0.86) |
FHAT | 0.74 (0.66 – 0.80) | 0.66 (0.55 – 0.76) | 0.83 (0.76 – 0.89) |
IBIS | 0.47 (0.28 – 0.69) | - | - |
BOADICEA | 0.74 (0.67 – 0.80) | 0.68 (0.56 – 0.79) | 0.77 (0.70 – 0.84) |
BRCA1 status | Â | Â | Â |
BRCAPRO | 0.80 (0.72 – 0.87) | 0.8 (0.62 – 0.91) | 0.81 (0.71 – 0.88) |
Manchester | 0.78 (0.69 – 0.86) | 0.74 (0.46 – 0.93) | 0.79 (0.69 – 0.88) |
Penn II | 0.79 (0.72 – 0.85) | 0.76 (0.61 – 0.86) | 0.81 (0.73 – 0.87) |
COUCH | 0.82 (0.75 – 0.87) | 0.82 (0.65 – 0.92) | 0.84 (0.75 – 0.89) |
IBIS | 0.43 (0.28 – 0.56) | - | - |
BOADICEA | 0.80 (0.72 – 0.86) | 0.79 (0.61 – 0.89) | 0.80 (0.71 – 0.87) |
BRCA2 status | Â | Â | Â |
BRCAPRO | 0.60 (0.50 – 0.68) | 0.57 (0.42 – 0.71) | 0.62 (0.48 – 0.73) |
Manchester | 0.60 (0.49 – 0.70) | 0.56 (0.34 – 0.74) | 0.63 (0.49 – 0.74) |
Penn II | 0.57 (0.48 – 0.65) | 0.54 (0.39 – 0.69) | 0.58 (0.46 – 0.69) |
IBIS | 0.58 (0.29 – 0.84) | - | - |
BOADICEA | 0.63 (0.54 – 0.73) | 0.59 (0.41 – 0.76) | 0.67 (0.55 – 0.77) |