Table 1 Specific methylation at Cytosine 8 & 20 in 31 human brain regions.
From: DNA methylation and mRNA expression of SYN III, a candidate gene for schizophrenia
Cytosine Number | ||||
|---|---|---|---|---|
31 Brain Regions (originating from one individual) and Blood | mRNA expression | Methylation status of the Cytosines in 3 CpG dinucleotides (see Figure 1 for cytosine numbering) | ||
3 | 8 | 20 | ||
Amygdala | Medium | ● | ○/● | ○/● |
BA5 Caudal Bank of Area 7 | High | ● | ○/● | ○/● |
Corpus Callosum | NA | ● | ○/● | ○/● |
Cerebellum | High | ● | ○/● | ○/● |
Cerebellar Vermis | High | ● | ○/● | ○/● |
Hippocampus | NA | NA | ○/● | ○/● |
Orbital Frontal Cortex | High | ● | ○/● | ○/● |
Putamen | Very low/absent | ● | ○/● | ○/● |
Temporal Lobe | NA | ● | ○/● | ○/● |
Thalamic Nucleus (Lateral) | NA | NA | ○/● | ○/● |
White Cortical Matter | NA | NA | ○/● | ○/● |
Cingulate Gyrus | Medium | ● | ○/● | ○/● |
Gray Cortical Matter | NA | ● | ○/● | ○/● |
Medulla Oblongata | High | ● | ○/● | ○/● |
Pons | Medium | ● | ○/● | ○/● |
Temporal Cortex (Inferior) | High | ● | ○/● | ○/● |
Visual Cortex (Occipital Pole) | High | ● | ○/● | ○/● |
Crus Cerebri Cerebral Peduncle | Very low/absent | ● | ○/● | ○/● |
Cingulate (Posterior Cortex) | High | ● | ○/● | ○/● |
Cingulate (Anterior Bilateral) | High | ● | ○/● | ○/● |
Cingulate (Anterior Cortex) | NA | ● | ○/● | ○/● |
Caudate (Head) | Very low/absent | ● | ○/● | ○/● |
Internal Capsule | Medium | ● | ○/● | ○/● |
Lentiform Nucleus (Posterior End) | Very low/absent | ● | ○/● | ○/● |
Red Nucleus (Bilateral) | Very low/absent | ● | ○/● | ○/● |
Thalamic Nucleus (Medial) | Very low/absent | ● | ○/● | ○/● |
Temporal Cortex (Superior) | Medium | ● | ○/● | ○/● |
Temporal Cortex (Medial) | High | ● | ○/● | ○/● |
Caudate Nucleus (Body) | Very low/absent | ● | ○/● | ○/● |
Internal Capsule (Posterior Limb) | NA | ● | ○/● | ○/● |
Thalamus (Lateral Geniculate Nucleus) | NA | ● | ○/● | ○/● |
Blood (from table 1) | NA | ● | ○/● | ○/●or ● |