Table 1 Distribution of C677T genotype frequencies in the 20th century.
From: Human genetic selection on the MTHFR 677C>T polymorphism
Frequencies by date of birth | ||||||||
|---|---|---|---|---|---|---|---|---|
C677T-MTHFR Genotype-Allele | 1900–1925 (n = 206) | 1926–1950 (n = 320) | 1951–1975 (n = 408) | 1976–2000 (n = 371) | ||||
% | n | % | n | % | n | % | n | |
CC | 0.393 | 81 | 0.394 | 126 | 0.37 | 151 | 0.299* | 111 |
CT | 0.495 | 102 | 0.488 | 156 | 0.49 | 200 | 0.461 | 171 |
TT | 0.112 | 23 | 0.119 | 38 | 0.14 | 57 | 0.24** | 89 |
C allele | 0.641 | 264 | 0.638 | 408 | 0.615 | 502 | 0.53** | 393 |
T allele | 0.359 | 148 | 0.363 | 232 | 0.385 | 314 | 0.47** | 349 |