SNP rs12413112 | Genotype | Calculation Model | ||||
---|---|---|---|---|---|---|
GG | GA | AA | padd | pdom | prec | |
n | 726 | 173 | 18 | |||
Sex (men/women), n | 266/460 | 72/101 | 6/12 | 0.45a | 0.29 | 0.71 |
Age (years) | 38.6 ± 12.5 | 38.9 ± 12.8 | 37.9 ± 13.9 | 0.92 | 0.86 | 0.71 |
Waist-to-hip ratio | 0.87 ± 0.09 | 0.87 ± 0.09 | 0.86 ± 0.12 | 0.69b | 0.39 | 0.80 |
BMI (kg/m2) | 29.3 ± 8.8 | 29.1 ± 8.0 | 29.7 ± 8.7 | 0.08 | 0.46 | 0.02 |
Body fat (%) | 30.4 ± 10.9 | 30.1 ± 11.2 | 34.0 ± 10.7 | 0.29 | 0.53 | 0.12 |
Fasting glucose (mmol/l) | 5.12 ± 0.66 | 5.13 ± 0.62 | 5.07 ± 0.55 | 0.87c | 0.83 | 0.61 |
2 h glucose (mmol/l) | 6.27 ± 1.73 | 6.42 ± 1.62 | 5.84 ± 1.79 | 0.07 | 0.42 | 0.08 |
Fasting insulin (pmol/l) | 64.8 ± 55.1 | 61.6 ± 47.0 | 63.5 ± 57.5 | 0.52 | 0.35 | 0.26 |
2 h insulin (pmol/l) | 429 ± 442 | 441 ± 366 | 397 ± 337 | 0.09 | 0.42 | 0.29 |
Insulin sensitivity (AU) | 16.6 ± 11.0 | 15.8 ± 10.7 | 16.6 ± 8.9 | 0.19 | 0.90 | 0.19 |
Insulin secretion (pmol/l) | 2046 ± 898 | 2115 ± 907 | 2172 ± 1054 | 0.68 | 0.49 | 0.53 |
Basal energy exp (kcal/24 h)d | 1730 ± 297 | 1746 ± 331 | 1655 ± 292 | 0.10 | 0.039 | 0.31 |
Respiratory quotientd | 0.81 ± 0.07 | 0.83 ± 0.07 | 0.81 ± 0.08 | 0.048 | 0.017 | 0.92 |
rs7069102 | GG | GC | CC | |||
n | 457 | 366 | 94 | |||
Sex (men/women), n | 172/285 | 138/228 | 34/60 | 0.96 | 0.94 | 0.78 |
Age (years) | 38.2 ± 12.2 | 39.4 ± 12.8 | 37.9 ± 13.1 | 0.36 | 0.26 | 0.48 |
Waist-to-hip ratio | 0.86 ± 0.09 | 0.87 ± 0.09 | 0.86 ± 0.10 | 0.84 | 0.92 | 0.56 |
BMI (kg/m2) | 29.5 ± 8.9 | 29.1 ± 8.7 | 28.8 ± 7.5 | 0.51 | 0.48 | 0.53 |
Body fat (%) | 30.5 ± 11.2 | 30.2 ± 10.7 | 30.6 ± 11.4 | 0.92 | 0.68 | 0.88 |
Fasting glucose (mmol/l) | 5.13 ± 0.68 | 5.12 ± 0.63 | 5.08 ± 0.55 | 0.79 | 0.64 | 0.65 |
2 h glucose (mmol/l) | 6.27 ± 1.74 | 6.30 ± 1.64 | 6.32 ± 1.86 | 0.94 | 0.89 | 0.73 |
Fasting insulin (pmol/l) | 65.2 ± 51.6 | 63.2 ± 56.6 | 62.3 ± 52.1 | 0.73 | 0.92 | 0.43 |
2 h insulin (pmol/l) | 441 ± 450 | 418 ± 401 | 432 ± 408 | 0.99 | 0.89 | 0.95 |
Insulin sensitivity (AU) | 16.7 ± 11.6 | 16.2 ± 10.4 | 16.2 ± 9.9 | 0.88 | 0.70 | 0.67 |
Insulin secretion (pmol/l) | 2091 ± 947 | 2017 ± 856 | 2097 ± 866 | 0.47 | 0.44 | 0.44 |
Basal energy exp (kcal/24 h) | 1742 ± 288 | 1734 ± 334 | 1680 ± 245 | 0.06 | 0.05 | 0.56 |
Respiratory quotient | 0.81 ± 0.07 | 0.82 ± 0.07 | 0.81 ± 0.07 | 0.35 | 0.18 | 0.90 |
rs730821 | AA | AG | GG | |||
n | 603 | 286 | 28 | |||
Sex (men/women), n | 237/366 | 94/192 | 13/15 | 0.11 | 0.12 | 0.33 |
Age (years) | 38.4 ± 12.4 | 39.3 ± 12.9 | 37.5 ± 13.4 | 0.59 | 0.37 | 0.58 |
Waist-to-hip ratio | 0.87 ± 0.09 | 0.87 ± 0.09 | 0.86 ± 0.12 | 0.38 | 0.55 | 0.28 |
BMI (kg/m2) | 29.5 ± 8.7 | 29.0 ± 8.6 | 27.7 ± 7.5 | 0.28 | 0.12 | 0.39 |
Body fat (%) | 30.4 ± 11.2 | 30.5 ± 10.4 | 27.2 ± 11.3 | 0.23 | 0.26 | 0.13 |
Fasting glucose (mmol/l) | 5.13 ± 0.67 | 5.11 ± 0.59 | 5.01 ± 0.66 | 0.39 | 0.66 | 0.22 |
2 h glucose (mmol/l) | 6.28 ± 1.72 | 6.31 ± 1.66 | 6.11 ± 2.10 | 0.34 | 0.92 | 0.14 |
Fasting insulin (pmol/l) | 65.1 ± 51.4 | 61.7 ± 57.5 | 68.8 ± 61.8 | 0.55 | 0.92 | 0.68 |
2 h insulin (pmol/l) | 443 ± 440 | 406 ± 387 | 433 ± 527 | 0.62 | 0.69 | 0.55 |
Insulin sensitivity (AU) | 16.5 ± 11.5 | 16.2 ± 9.6 | 18.1 ± 12.3 | 0.80 | 0.82 | 0.91 |
Insulin secretion (pmol/l) | 2098 ± 945 | 1997 ± 822 | 1929 ± 694 | 0.68 | 0.38 | 0.64 |
Basal energy exp (kcal/24 h) | 1746 ± 305 | 1714 ± 306 | 1642 ± 217 | 0.89 | 0.86 | 0.63 |
Respiratory quotient | 0.82 ± 0.07 | 0.81 ± 0.07 | 0.82 ± 0.08 | 0.79 | 0.48 | 0.88 |
rs2273773 | TT | TC | CC | |||
n | 812 | 103 | 2 | |||
Sex (men/women), n | 313/499 | 30/73 | 1/1 | 0.16 | 0.07 | 0.72 |
Age (years) | 38.7 ± 12.4 | 38.5 ± 13.6 | 33.0 ± 4.2 | 0.82 | 0.80 | 0.66 |
Waist-to-hip ratio | 0.87 ± 0.09 | 0.86 ± 0.10 | 0.77 ± 0.02 | 0.10 | 0.68 | 0.04 |
BMI (kg/m2) | 29.3 ± 8.9 | 29.2 ± 7.2 | 24.3 ± 7.1 | 0.72 | 0.99 | 0.42 |
Body fat (%) | 30.2 ± 11.1 | 31.9 ± 9.7 | 28.0 ± 18.4 | 0.78 | 0.52 | 0.84 |
Fasting glucose (mmol/l) | 5.13 ± 0.65 | 5.05 ± 0.62 | 4.96 ± 0.09 | 0.19 | 0.35 | 0.93 |
2 h glucose (mmol/l) | 6.27 ± 1.71 | 6.47 ± 1.75 | 4.58 ± 0.35 | 0.39 | 0.31 | 0.18 |
Fasting insulin (pmol/l) | 63.4 ± 50.5 | 70.2 ± 74.3 | 33.0 ± 22.6 | 0.44 | 0.61 | 0.22 |
2 h insulin (pmol/l) | 426 ± 417 | 470 ± 494 | 178 ± 212 | 0.17 | 0.71 | 0.06 |
Insulin sensitivity (AU) | 16.5 ± 11.0 | 15.9 ± 10.1 | 26.7 ± 14.1 | 0.38 | 0.82 | 0.21 |
Insulin secretion (pmol/l) | 2070 ± 908 | 2019 ± 864 | 1299 ± 41 | 0.45 | 0.34 | 0.39 |
Basal energy exp (kcal/24 h) | 1730 ± 304 | 1756 ± 310 | 1835 ± 0 | 0.33 | 0.16 | 0.51 |
Respiratory quotient | 0.82 ± 0.07 | 0.80 ± 0.08 | 0.84 ± 0 | 0.19 | 0.09 | 0.94 |