Skip to main content

Advertisement

Table 1 Distribution of anthropometrics and metabolic traits in the TUEF cohort according to rs12413112, rs7069102, rs730821 and rs2273773 in SIRT1

From: SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention – the TULIP Study

SNP rs12413112 Genotype Calculation Model
  GG GA AA padd pdom prec
n 726 173 18    
Sex (men/women), n 266/460 72/101 6/12 0.45a 0.29 0.71
Age (years) 38.6 ± 12.5 38.9 ± 12.8 37.9 ± 13.9 0.92 0.86 0.71
Waist-to-hip ratio 0.87 ± 0.09 0.87 ± 0.09 0.86 ± 0.12 0.69b 0.39 0.80
BMI (kg/m2) 29.3 ± 8.8 29.1 ± 8.0 29.7 ± 8.7 0.08 0.46 0.02
Body fat (%) 30.4 ± 10.9 30.1 ± 11.2 34.0 ± 10.7 0.29 0.53 0.12
Fasting glucose (mmol/l) 5.12 ± 0.66 5.13 ± 0.62 5.07 ± 0.55 0.87c 0.83 0.61
2 h glucose (mmol/l) 6.27 ± 1.73 6.42 ± 1.62 5.84 ± 1.79 0.07 0.42 0.08
Fasting insulin (pmol/l) 64.8 ± 55.1 61.6 ± 47.0 63.5 ± 57.5 0.52 0.35 0.26
2 h insulin (pmol/l) 429 ± 442 441 ± 366 397 ± 337 0.09 0.42 0.29
Insulin sensitivity (AU) 16.6 ± 11.0 15.8 ± 10.7 16.6 ± 8.9 0.19 0.90 0.19
Insulin secretion (pmol/l) 2046 ± 898 2115 ± 907 2172 ± 1054 0.68 0.49 0.53
Basal energy exp (kcal/24 h)d 1730 ± 297 1746 ± 331 1655 ± 292 0.10 0.039 0.31
Respiratory quotientd 0.81 ± 0.07 0.83 ± 0.07 0.81 ± 0.08 0.048 0.017 0.92
rs7069102 GG GC CC    
n 457 366 94    
Sex (men/women), n 172/285 138/228 34/60 0.96 0.94 0.78
Age (years) 38.2 ± 12.2 39.4 ± 12.8 37.9 ± 13.1 0.36 0.26 0.48
Waist-to-hip ratio 0.86 ± 0.09 0.87 ± 0.09 0.86 ± 0.10 0.84 0.92 0.56
BMI (kg/m2) 29.5 ± 8.9 29.1 ± 8.7 28.8 ± 7.5 0.51 0.48 0.53
Body fat (%) 30.5 ± 11.2 30.2 ± 10.7 30.6 ± 11.4 0.92 0.68 0.88
Fasting glucose (mmol/l) 5.13 ± 0.68 5.12 ± 0.63 5.08 ± 0.55 0.79 0.64 0.65
2 h glucose (mmol/l) 6.27 ± 1.74 6.30 ± 1.64 6.32 ± 1.86 0.94 0.89 0.73
Fasting insulin (pmol/l) 65.2 ± 51.6 63.2 ± 56.6 62.3 ± 52.1 0.73 0.92 0.43
2 h insulin (pmol/l) 441 ± 450 418 ± 401 432 ± 408 0.99 0.89 0.95
Insulin sensitivity (AU) 16.7 ± 11.6 16.2 ± 10.4 16.2 ± 9.9 0.88 0.70 0.67
Insulin secretion (pmol/l) 2091 ± 947 2017 ± 856 2097 ± 866 0.47 0.44 0.44
Basal energy exp (kcal/24 h) 1742 ± 288 1734 ± 334 1680 ± 245 0.06 0.05 0.56
Respiratory quotient 0.81 ± 0.07 0.82 ± 0.07 0.81 ± 0.07 0.35 0.18 0.90
rs730821 AA AG GG    
n 603 286 28    
Sex (men/women), n 237/366 94/192 13/15 0.11 0.12 0.33
Age (years) 38.4 ± 12.4 39.3 ± 12.9 37.5 ± 13.4 0.59 0.37 0.58
Waist-to-hip ratio 0.87 ± 0.09 0.87 ± 0.09 0.86 ± 0.12 0.38 0.55 0.28
BMI (kg/m2) 29.5 ± 8.7 29.0 ± 8.6 27.7 ± 7.5 0.28 0.12 0.39
Body fat (%) 30.4 ± 11.2 30.5 ± 10.4 27.2 ± 11.3 0.23 0.26 0.13
Fasting glucose (mmol/l) 5.13 ± 0.67 5.11 ± 0.59 5.01 ± 0.66 0.39 0.66 0.22
2 h glucose (mmol/l) 6.28 ± 1.72 6.31 ± 1.66 6.11 ± 2.10 0.34 0.92 0.14
Fasting insulin (pmol/l) 65.1 ± 51.4 61.7 ± 57.5 68.8 ± 61.8 0.55 0.92 0.68
2 h insulin (pmol/l) 443 ± 440 406 ± 387 433 ± 527 0.62 0.69 0.55
Insulin sensitivity (AU) 16.5 ± 11.5 16.2 ± 9.6 18.1 ± 12.3 0.80 0.82 0.91
Insulin secretion (pmol/l) 2098 ± 945 1997 ± 822 1929 ± 694 0.68 0.38 0.64
Basal energy exp (kcal/24 h) 1746 ± 305 1714 ± 306 1642 ± 217 0.89 0.86 0.63
Respiratory quotient 0.82 ± 0.07 0.81 ± 0.07 0.82 ± 0.08 0.79 0.48 0.88
rs2273773 TT TC CC    
n 812 103 2    
Sex (men/women), n 313/499 30/73 1/1 0.16 0.07 0.72
Age (years) 38.7 ± 12.4 38.5 ± 13.6 33.0 ± 4.2 0.82 0.80 0.66
Waist-to-hip ratio 0.87 ± 0.09 0.86 ± 0.10 0.77 ± 0.02 0.10 0.68 0.04
BMI (kg/m2) 29.3 ± 8.9 29.2 ± 7.2 24.3 ± 7.1 0.72 0.99 0.42
Body fat (%) 30.2 ± 11.1 31.9 ± 9.7 28.0 ± 18.4 0.78 0.52 0.84
Fasting glucose (mmol/l) 5.13 ± 0.65 5.05 ± 0.62 4.96 ± 0.09 0.19 0.35 0.93
2 h glucose (mmol/l) 6.27 ± 1.71 6.47 ± 1.75 4.58 ± 0.35 0.39 0.31 0.18
Fasting insulin (pmol/l) 63.4 ± 50.5 70.2 ± 74.3 33.0 ± 22.6 0.44 0.61 0.22
2 h insulin (pmol/l) 426 ± 417 470 ± 494 178 ± 212 0.17 0.71 0.06
Insulin sensitivity (AU) 16.5 ± 11.0 15.9 ± 10.1 26.7 ± 14.1 0.38 0.82 0.21
Insulin secretion (pmol/l) 2070 ± 908 2019 ± 864 1299 ± 41 0.45 0.34 0.39
Basal energy exp (kcal/24 h) 1730 ± 304 1756 ± 310 1835 ± 0 0.33 0.16 0.51
Respiratory quotient 0.82 ± 0.07 0.80 ± 0.08 0.84 ± 0 0.19 0.09 0.94
  1. Data are presented as means ± SD; AU, arbitrary units
  2. aAccording to χ2 test; bWaist-to-hip ratio, body mass index (BMI) and body fat were adjusted for age and sex; cAll the following parameters were adjusted for age, sex and body fat; insulin secretion was additionally adjusted for insulin sensitivity; d n = 375 participants; basal energy expenditure was adjusted to age, sex, lean body mass and body fat.