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Table 1 Distribution of anthropometrics and metabolic traits in the TUEF cohort according to rs12413112, rs7069102, rs730821 and rs2273773 in SIRT1

From: SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention – the TULIP Study

SNP rs12413112

Genotype

Calculation Model

 

GG

GA

AA

padd

pdom

prec

n

726

173

18

   

Sex (men/women), n

266/460

72/101

6/12

0.45a

0.29

0.71

Age (years)

38.6 ± 12.5

38.9 ± 12.8

37.9 ± 13.9

0.92

0.86

0.71

Waist-to-hip ratio

0.87 ± 0.09

0.87 ± 0.09

0.86 ± 0.12

0.69b

0.39

0.80

BMI (kg/m2)

29.3 ± 8.8

29.1 ± 8.0

29.7 ± 8.7

0.08

0.46

0.02

Body fat (%)

30.4 ± 10.9

30.1 ± 11.2

34.0 ± 10.7

0.29

0.53

0.12

Fasting glucose (mmol/l)

5.12 ± 0.66

5.13 ± 0.62

5.07 ± 0.55

0.87c

0.83

0.61

2 h glucose (mmol/l)

6.27 ± 1.73

6.42 ± 1.62

5.84 ± 1.79

0.07

0.42

0.08

Fasting insulin (pmol/l)

64.8 ± 55.1

61.6 ± 47.0

63.5 ± 57.5

0.52

0.35

0.26

2 h insulin (pmol/l)

429 ± 442

441 ± 366

397 ± 337

0.09

0.42

0.29

Insulin sensitivity (AU)

16.6 ± 11.0

15.8 ± 10.7

16.6 ± 8.9

0.19

0.90

0.19

Insulin secretion (pmol/l)

2046 ± 898

2115 ± 907

2172 ± 1054

0.68

0.49

0.53

Basal energy exp (kcal/24 h)d

1730 ± 297

1746 ± 331

1655 ± 292

0.10

0.039

0.31

Respiratory quotientd

0.81 ± 0.07

0.83 ± 0.07

0.81 ± 0.08

0.048

0.017

0.92

rs7069102

GG

GC

CC

   

n

457

366

94

   

Sex (men/women), n

172/285

138/228

34/60

0.96

0.94

0.78

Age (years)

38.2 ± 12.2

39.4 ± 12.8

37.9 ± 13.1

0.36

0.26

0.48

Waist-to-hip ratio

0.86 ± 0.09

0.87 ± 0.09

0.86 ± 0.10

0.84

0.92

0.56

BMI (kg/m2)

29.5 ± 8.9

29.1 ± 8.7

28.8 ± 7.5

0.51

0.48

0.53

Body fat (%)

30.5 ± 11.2

30.2 ± 10.7

30.6 ± 11.4

0.92

0.68

0.88

Fasting glucose (mmol/l)

5.13 ± 0.68

5.12 ± 0.63

5.08 ± 0.55

0.79

0.64

0.65

2 h glucose (mmol/l)

6.27 ± 1.74

6.30 ± 1.64

6.32 ± 1.86

0.94

0.89

0.73

Fasting insulin (pmol/l)

65.2 ± 51.6

63.2 ± 56.6

62.3 ± 52.1

0.73

0.92

0.43

2 h insulin (pmol/l)

441 ± 450

418 ± 401

432 ± 408

0.99

0.89

0.95

Insulin sensitivity (AU)

16.7 ± 11.6

16.2 ± 10.4

16.2 ± 9.9

0.88

0.70

0.67

Insulin secretion (pmol/l)

2091 ± 947

2017 ± 856

2097 ± 866

0.47

0.44

0.44

Basal energy exp (kcal/24 h)

1742 ± 288

1734 ± 334

1680 ± 245

0.06

0.05

0.56

Respiratory quotient

0.81 ± 0.07

0.82 ± 0.07

0.81 ± 0.07

0.35

0.18

0.90

rs730821

AA

AG

GG

   

n

603

286

28

   

Sex (men/women), n

237/366

94/192

13/15

0.11

0.12

0.33

Age (years)

38.4 ± 12.4

39.3 ± 12.9

37.5 ± 13.4

0.59

0.37

0.58

Waist-to-hip ratio

0.87 ± 0.09

0.87 ± 0.09

0.86 ± 0.12

0.38

0.55

0.28

BMI (kg/m2)

29.5 ± 8.7

29.0 ± 8.6

27.7 ± 7.5

0.28

0.12

0.39

Body fat (%)

30.4 ± 11.2

30.5 ± 10.4

27.2 ± 11.3

0.23

0.26

0.13

Fasting glucose (mmol/l)

5.13 ± 0.67

5.11 ± 0.59

5.01 ± 0.66

0.39

0.66

0.22

2 h glucose (mmol/l)

6.28 ± 1.72

6.31 ± 1.66

6.11 ± 2.10

0.34

0.92

0.14

Fasting insulin (pmol/l)

65.1 ± 51.4

61.7 ± 57.5

68.8 ± 61.8

0.55

0.92

0.68

2 h insulin (pmol/l)

443 ± 440

406 ± 387

433 ± 527

0.62

0.69

0.55

Insulin sensitivity (AU)

16.5 ± 11.5

16.2 ± 9.6

18.1 ± 12.3

0.80

0.82

0.91

Insulin secretion (pmol/l)

2098 ± 945

1997 ± 822

1929 ± 694

0.68

0.38

0.64

Basal energy exp (kcal/24 h)

1746 ± 305

1714 ± 306

1642 ± 217

0.89

0.86

0.63

Respiratory quotient

0.82 ± 0.07

0.81 ± 0.07

0.82 ± 0.08

0.79

0.48

0.88

rs2273773

TT

TC

CC

   

n

812

103

2

   

Sex (men/women), n

313/499

30/73

1/1

0.16

0.07

0.72

Age (years)

38.7 ± 12.4

38.5 ± 13.6

33.0 ± 4.2

0.82

0.80

0.66

Waist-to-hip ratio

0.87 ± 0.09

0.86 ± 0.10

0.77 ± 0.02

0.10

0.68

0.04

BMI (kg/m2)

29.3 ± 8.9

29.2 ± 7.2

24.3 ± 7.1

0.72

0.99

0.42

Body fat (%)

30.2 ± 11.1

31.9 ± 9.7

28.0 ± 18.4

0.78

0.52

0.84

Fasting glucose (mmol/l)

5.13 ± 0.65

5.05 ± 0.62

4.96 ± 0.09

0.19

0.35

0.93

2 h glucose (mmol/l)

6.27 ± 1.71

6.47 ± 1.75

4.58 ± 0.35

0.39

0.31

0.18

Fasting insulin (pmol/l)

63.4 ± 50.5

70.2 ± 74.3

33.0 ± 22.6

0.44

0.61

0.22

2 h insulin (pmol/l)

426 ± 417

470 ± 494

178 ± 212

0.17

0.71

0.06

Insulin sensitivity (AU)

16.5 ± 11.0

15.9 ± 10.1

26.7 ± 14.1

0.38

0.82

0.21

Insulin secretion (pmol/l)

2070 ± 908

2019 ± 864

1299 ± 41

0.45

0.34

0.39

Basal energy exp (kcal/24 h)

1730 ± 304

1756 ± 310

1835 ± 0

0.33

0.16

0.51

Respiratory quotient

0.82 ± 0.07

0.80 ± 0.08

0.84 ± 0

0.19

0.09

0.94

  1. Data are presented as means ± SD; AU, arbitrary units
  2. aAccording to χ2 test; bWaist-to-hip ratio, body mass index (BMI) and body fat were adjusted for age and sex; cAll the following parameters were adjusted for age, sex and body fat; insulin secretion was additionally adjusted for insulin sensitivity; d n = 375 participants; basal energy expenditure was adjusted to age, sex, lean body mass and body fat.