Table 4 Candidate gene evaluation
From: Framingham Heart Study genome-wide association: results for pulmonary function measures
Gene region | Chr | SNP | Phenotype | FBAT p-value | GEE p-value |
|---|---|---|---|---|---|
Alpha-1-antitrypsin (AAT/SERPINA1) | 14 | rs2402446 rs10484042 | ppfvc fev1slope | 0.02 0.90 | 0.30 0.01 |
Beta-2 adrenergic receptor (ADRB2) | 5 | rs30329 rs9325117 | fefslope meanratio | 0.009 - | 0.07 0.04 |
cystic fibrosis transmembrane regulator (CFTR) | 7 | rs213987 rs10487367 | meanfvc ppratio | 0.006 0.25 | 0.38 0.002 |
Microsomal epoxide hydrolase (EPHX1) | 1 | rs3738051 | fefslope ppfefrat | 0.01 0.03 | 0.30 0.04 |
Vitamin D binding protein (GC) | 4 | rs423817 rs842873 | ppfefrat ppfefrat | 0.0009 0.05 | 0.06 0.02 |
Glutathione S-transferase M2 (GSTM2) | 1 | rs542338 | meanratio fev1slope | 0.19 0.43 | 0.63 0.20 |
Glutathione S-transferase O2 (GSTO2) | 10 | rs156697 | meanfvc | 9.4 × 10 -05 | 9.8 × 10 -06 |
Glutathione S-transferase P1 (GSTP1) | 11 | rs688878 | ppfefrat ppfvc | 0.07 0.39 | 0.35 0.02 |
Glutathione S-transferase T2 (GSTT2) | 22 | rs140289 | ppfvc ppfev1 | 0.17 0.41 | 0.13 0.10 |
Heme oxygenase (HMOX1) | 22 | rs2267331 rs10483190 | fev1slope meanratio | 0.07 0.82 | 0.80 0.008 |
Interleukin-10 (IL10) | 1 | rs10494879 | fefslope fev1slope | 0.06 0.46 | 0.73 0.02 |
Matrix metalloproteinase-1 (MMP1) | 11 | rs495366 | fefslope ppfef | 0.02 0.20 | 0.13 0.03 |
Matrix metalloproteinase-9 (MMP9) | 20 | rs2903908 | ppfefrat | 0.19 | 0.05 |
Alpha-1-antichymotrypsin (SERPINA3) | 14 | rs10484047 | ppfvc fev1slope | 0.02 0.10 | 0.03 0.01 |
Serine proteinase inhibitor E2 (SERPINE2) | 2 | rs717610 | meanfvc meanratio | 0.04 0.19 | 0.003 0.001 |
Surfactant protein B (SFTPB) | 2 | rs7577293 | meanratio | 0.02 | 0.06 |
Surfactant protein D (SFTPD) | 10 | rs726289 | fefslope | 0.02 | 0.03 |
extracellular super oxide dismutase (SOD3) | 4 | rs10489030 | ppfev1 ppfvc | 0.0005 0.01 | 0.02 0.007 |
transforming growth factor beta-1 (TGFB1) | 19 | rs3745295 | fev1slope ppfev1 | 0.21 0.74 | 0.62 0.18 |
Tissue inhibitor of metalloproteases-2 (TIMP2) | 17 | rs2889529 | ppfef meanratio | 0.07 0.18 | 0.11 0.09 |