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Table 4 Candidate gene evaluation

From: Framingham Heart Study genome-wide association: results for pulmonary function measures

Gene region Chr SNP Phenotype FBAT p-value GEE p-value
Alpha-1-antitrypsin (AAT/SERPINA1) 14 rs2402446
rs10484042
ppfvc
fev1slope
0.02
0.90
0.30
0.01
Beta-2 adrenergic receptor (ADRB2) 5 rs30329
rs9325117
fefslope
meanratio
0.009
-
0.07
0.04
cystic fibrosis transmembrane regulator (CFTR) 7 rs213987
rs10487367
meanfvc
ppratio
0.006
0.25
0.38
0.002
Microsomal epoxide hydrolase (EPHX1) 1 rs3738051 fefslope
ppfefrat
0.01
0.03
0.30
0.04
Vitamin D binding protein (GC) 4 rs423817
rs842873
ppfefrat
ppfefrat
0.0009
0.05
0.06
0.02
Glutathione S-transferase M2 (GSTM2) 1 rs542338 meanratio
fev1slope
0.19
0.43
0.63
0.20
Glutathione S-transferase O2 (GSTO2) 10 rs156697 meanfvc 9.4 × 10 -05 9.8 × 10 -06
Glutathione S-transferase P1 (GSTP1) 11 rs688878 ppfefrat
ppfvc
0.07
0.39
0.35
0.02
Glutathione S-transferase T2 (GSTT2) 22 rs140289 ppfvc
ppfev1
0.17
0.41
0.13
0.10
Heme oxygenase (HMOX1) 22 rs2267331
rs10483190
fev1slope
meanratio
0.07
0.82
0.80
0.008
Interleukin-10 (IL10) 1 rs10494879 fefslope
fev1slope
0.06
0.46
0.73
0.02
Matrix metalloproteinase-1 (MMP1) 11 rs495366 fefslope
ppfef
0.02
0.20
0.13
0.03
Matrix metalloproteinase-9 (MMP9) 20 rs2903908 ppfefrat 0.19 0.05
Alpha-1-antichymotrypsin (SERPINA3) 14 rs10484047 ppfvc
fev1slope
0.02
0.10
0.03
0.01
Serine proteinase inhibitor E2 (SERPINE2) 2 rs717610 meanfvc
meanratio
0.04
0.19
0.003
0.001
Surfactant protein B (SFTPB) 2 rs7577293 meanratio 0.02 0.06
Surfactant protein D (SFTPD) 10 rs726289 fefslope 0.02 0.03
extracellular super oxide dismutase (SOD3) 4 rs10489030 ppfev1
ppfvc
0.0005
0.01
0.02
0.007
transforming growth factor beta-1 (TGFB1) 19 rs3745295 fev1slope
ppfev1
0.21
0.74
0.62
0.18
Tissue inhibitor of metalloproteases-2 (TIMP2) 17 rs2889529 ppfef
meanratio
0.07
0.18
0.11
0.09
  1. Best p-value for FBAT and GEE tests reported with specific SNP*phenotype producing result. P-values < 0.01 bolded.