From: Framingham Heart Study genome-wide association: results for pulmonary function measures
2a Top Association results based on GEE p-value | ||||||
---|---|---|---|---|---|---|
Phenotype | SNP | Chr | Physical position | GEE p-value | FBAT p-value | Gene Region |
fev1slope | 1. rs3867498 | 15 | 22629880 | 1.36 × 10 -06 | 0.07 | SNRPN |
meanfvc | 2. rs441051 | 7 | 93698651 | 2.16 × 10 -06 | 0.005 | COL1A2 |
meanratio | 3. rs2838815 | 21 | 45454018 | 2.63 × 10 -06 | 0.0002 | ADARB1 |
ppfvc | 4. rs1455782 | 15 | 90851970 | 4.23 × 10 -06 | 0.18 | FLJ32831 |
meanfvc | 5. rs10516541 | 4 | 108472826 | 4.32 × 10 -06 | 7.19 × 10-05 |  |
meanfev1 |  |  |  | 1.7 × 10 -05 | 0.0002 |  |
ppratio | 6. rs310558 | 8 | 51575144 | 5.14 × 10 -06 | 0.14 | SNTG1 |
ppfev1 | 7. rs3820928 | 2 | 227598971 | 5.33 × 10 -06 | 0.0005 | RHBDD1 |
ppfef | 8. rs730532 | 14 | 51588561 | 5.89 × 10 -06 | 0.15 | NID2 |
ppfefrat | 9. rs808225 | 14 | 57467669 | 7.38 × 10 -06 | 0.0008 |  |
ppratio |  |  |  | 1.45 × 10 -05 | 0.007 |  |
ppfef | 10. rs4129267 | 1 | 151239337 | 7.39 × 10 -06 | 0.07 | IL6R |
ppfev1 | 11. rs2906966* | 17 | 15272242 | 8.31 × 10 -06 | 5.03 × 10-05 | CDRT4 |
ppfvc | 12. rs357394 | 7 | 137506642 | 8.77 × 10 -06 | 0.14 |  |
fefslope | 13. rs1994169 | 12 | 33436783 | 9.55 × 10 -06 | 0.05 | SYT10 |
meanratio | 14. rs2225434 | 21 | 45458574 | 9.68 × 10 -06 | 0.0004 | ADARB1 |
meanfvc | 15. rs156697(a) | 10 | 106029175 | 9.78 × 10 -06 | 9.42 × 10-05 | GSTO2 |
meanfev1 |  |  |  | 1.8 × 10 -05 | 0.002 |  |
ppfefrat | 16. rs564425 | 13 | 46797096 | 1.03 × 10 -05 | 0.02 |  |
ppfef | 17. rs10498441 | 14 | 51613974 | 1.06 × 10 -05 | 0.28 | NID2 |
ppratio | 18. rs880713 | 2 | 128847844 | 1.11 × 10 -05 | 0.26 | AK128224 |
ppfefrat | 19. rs811732 | 14 | 57456738 | 1.3 × 10 -05 | 0.20 |  |
ppfvc | 20. rs6558132 | 8 | 29526866 | 1.58 × 10 -05 | 0.74 |  |
fev1slope | 21. rs6972823 | 7 | 3009137 | 1.69 × 10 -05 | 0.10 |  |
ppfef | 22. rs9285611(b) | 1 | 81895076 | 1.7 × 10 -05 | 0.07 |  |
meanfev1 | 23. rs10504836 | 8 | 88669709 | 1.72 × 10 -05 | 0.28 |  |
meanfev1 | 24. rs1491520 | 3 | 193243153 | 1.77 × 10 -05 | 0.12 |  |
ppfvc | 25. rs9300826 | 13 | 103001176 | 1.79 × 10 -05 | 0.11 |  |
2b Top Association results based on FBAT p-value | ||||||
Phenotype | SNP | Chr | Physical position | GEE p-value | FBAT p-value | Gene Region |
ppratio | 1. rs10922530 | 1 | 89139273 | 0.001 | 8.7 × 10 -07 | CCBL2 |
ppfefrat |  |  |  | 0.002 | 3.78 × 10 -06 |  |
ppfef |  |  |  | 0.005 | 2.36 × 10 -05 |  |
ppfefrat | 2. rs3753683 | 1 | 89139592 | 0.004 | 1.87 × 10 -06 | CCBL2 |
ppratio |  |  |  | 0.004 | 3.59 × 10 -06 |  |
ppfef |  |  |  | 0.01 | 1.42 × 10 -05 |  |
ppratio | 3. rs219349 | 14 | 59525168 | 0.01 | 6.15 × 10 -06 | LRRC9 |
ppfefrat |  |  |  | 0.04 | 4.91 × 10 -05 |  |
ppratio | 4. rs219391 | 14 | 59554684 | 0.02 | 6.18 × 10 -06 | LRRC9 |
ppratio | 5. rs219326 | 14 | 59512943 | 0.02 | 8.51 × 10 -06 | LRRC9 |
ppfefrat |  |  |  | 0.06 | 3.74 × 10 -05 |  |
ppfefrat | 6. rs1409149 | 1 | 89141170 | 0.005 | 9.12 × 10 -06 | CCBL2 |
ppratio |  |  |  | 0.005 | 1.08 × 10 -05 |  |
ppfef |  |  |  | 0.01 | 5.14 × 10 -05 |  |
ppfvc | 7. rs9299191 | 9 | 110944100 | 0.009 | 1.79 × 10 -05 |  |
meanfvc | 8. rs10515289(c) | 5 | 99315845 | 0.17 | 2.21 × 10 -05 |  |
ppfvc | 9. rs10498137 | 2 | 222966943 | 0.05 | 2.23 × 10 -05 | PAX3 |
ppfef | 10. rs3858282 | 10 | 90424391 | 0.001 | 2.92 × 10 -05 | LIPF |
ppratio | 11. rs905367 | 4 | 59896363 | 0.02 | 2.95 × 10 -05 |  |
meanfvc | 12. rs10495872 | 2 | 37915266 | 0.05 | 3.02 × 10 -05 |  |
fev1slope | 13. rs1347222 | 12 | 80896622 | 0.01 | 3.27 × 10 -05 |  |
ppratio | 14. rs2009488 | 4 | 59895895 | 0.03 | 3.43 × 10 -05 |  |
meanfvc | 15. rs6481257 | 10 | 58608558 | 0.02 | 3.52 × 10 -05 |  |
ppratio | 16. rs461951 | 14 | 59608986 | 0.02 | 3.63 × 10 -05 | LRRC9 |
meanfev1 | 17. rs491552 | 6 | 151403169 | 0.01 | 3.86 × 10 -05 | MTHFD1L |
meanfev1 | 18. rs1910137 | 4 | 27087329 | 0.08 | 4.04 × 10 -05 |  |
ppfvc | 19. rs2831605(d) | 21 | 28467064 | 0.03 | 4.41 × 10 -05 |  |
ppfev1 | 20. rs2906966* | 17 | 15272242 | 8.31 × 10-06 | 5.03 × 10 -05 | CDRT4 |
fefslope | 21. rs6740919 | 2 | 67531706 | 0.0009 | 5.17 × 10 -05 | ETAA16 |
meanfev1 | 22. rs10498818 | 6 | 63134129 | 0.02 | 5.25 × 10 -05 |  |
ppfefrat | 23. rs1393593 | 4 | 59907689 | 0.06 | 5.44 × 10 -05 |  |
ppfefrat | 24. rs9312080 | 4 | 59891451 | 0.11 | 5.63 × 10 -05 |  |
ppfefrat | 25. rs7851363 | 9 | 20748306 | 0.006 | 5.7 × 10 -05 | KIAA1797 |
2c Linkage peaks with LOD score > 2.0 | ||||||
Phenotype | SNP | Chr | Physical position | 1.5-LOD interval start | 1.5-LOD interval end | LOD score |
meanfev1 | rs2300081 | 6 | 168097526 | 165513097 | 170788550 | 2.89 |
fefslope | rs5909594 | X(e) | 118057198 | 113970434 | 124311695 | 2.86 |
ppfev1 | AGC001b | 6 | 170788550 | 164268152 | 170788550 | 2.65 |
ppratio | rs10497042 | 2 | 150675813 | 148296793 | 154203261 | 2.40 |
meanratio | rs10518669 | 1 | 82811739 | 74999965 | 88728520(b) | 2.37 |
ppfef | rs2974490 | 5 | 113433775 | 95608129 | 124687730(c) | 2.29 |
meanfvc | rs10488908 | 21 | 21904704 | 19805361 | 34461762(d) | 2.29 |
ppfev1 | rs10518032 | 4 | 170322764 | 161768472 | 181501690 | 2.28 |
ppfvc | rs10489542 | 1 | 225169260 | 213625196 | 233478438 | 2.17 |
ppfef | rs721411 | 17 | 36902470 | 28313357 | 52519635 | 2.17 |
ppfev1 | rs753765 | 17 | 57323782 | 45345729 | 59677087 | 2.17 |
meanfev1 | rs4918762 | 10 | 114389096 | 102080914 | 122214789(a) | 2.12 |
ppfvc | rs10517825 | 4 | 166251091 | 156507719 | 191091333 | 2.02 |