Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study

Table 5 Candidate gene associations with electrocardiographic and heart rate variability traits

Candidate Gene	SNP	Chrom	Physical position	Minor allele frequency	Phenotype	GEE P-value
QT interval
NOS1AP	rs10494365	1	158815647	0.11	QT	0.01
NOS1AP	rs10494366	1	158817343	0.39	QT	9.0 × 10^-4
NOS1AP	rs6683968	1	158923070	0.32	QT	1.0 × 10^-4
NOS1AP	rs347311	1	159035565	0.28	QT	0.01
NOS1AP	rs945713	1	158867328	0.42	QT	2.4 × 10^-4
NOS1AP	rs1932933	1	158849704	0.39	QT	4.3 × 10^-4
RR interval
ADRA1A	rs10503797	8	26659190	0.11	RR	0.04
ADRB2	rs10515621	5	148226737	0.14	RR	0.04
PR interval
ADRA1A	rs520180	8	26765839	0.25	PR	0.04
LF/HF power
NA
Total power
ADRA1B	rs2195926	5	159255501	0.31	TP	0.01
ADRB2	rs9325124	5	148229011	0.44	TP	0.03
SDNN
ADRA1A	rs10503791	8	26611431	0.17	SDNN	0.02
ADRA1B	rs2195926	5	159255501	0.31	SDNN	0.03
ADRA1A	rs10503788	8	26611063	0.18	SDNN	0.01
ADRA1A	rs10503789	8	26611248	0.18	SDNN	0.01
ADRA1A	rs10503790	8	26611360	0.18	SDNN	0.01
ADRA1A	rs10503794	8	26612682	0.18	SDNN	0.01
ADRA1A	rs7000280	8	26611857	0.18	SDNN	0.01

Associations with QT interval of SNPs within 60 kb of candidate genes implicated in congenital Long QT Syndrome or QT duration and with RR and PR interval, low frequency to high frequency power (LF/HF), total power, and the standard deviation of normal RR intervals (SDNN) of SNPs within 60 kb of adrenergic receptor genes at a nominal p < 0.05 are shown.*
*SNPs with minor allele frequency <10%, call rate <80% or Hardy-Weinberg p-value < 0.001 were excluded. Candidate gene loci tested for association with QT interval duration include 88 SNPs within 60 kb of the following genes: KCNQ1, KCNH2, SCN5A, ANK2, KCNE1, KCNE2, KCNJ2, CACNA1C and NOS1AP. Candidate gene loci tested for association with RR, PR, LF/HF, total power, and SDNN include 35 SNPs within 60 kb of the following genes: ADRB1, ADRB2, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, and ADRA2C.

ISSN: 1471-2350